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Updated Perspectives on the Role of Estrogens in Skin Aging | CCID

Updated Perspectives on the Role of Estrogens in Skin Aging | CCID

Source : https://doi.org/10.2147/CCID.S333663

For many years, it has been recognized that estrogens are important in the maintenance of human skin. Women seek cosmetic and medical treatments to improve dermal health and physical characteristics to enhance their self-perception and inhibit skin aging, particularly in highly visible body areas.


Conclusion: Especially where skin collagen and elastin profiles are known to follow 17β-estradiol levels during aging and at/after menopause. Finally, the classification of isoflavonoid compounds as endocrine disruptors is unwarranted. In fact, isoflavonoids act as SERMs that bind to ER in the skin to enhance dermal health. Whereas the topical estrogen analog (MEP) has presumed mechanisms of action as a skin treatment.

  • August 23, 2022
    Key Points
    • Source: Clinical, Cosmetic and Investigational Dermatology
    • Relevance: “The narrative for this overview focuses on updating the factors that influence skin aging and the important role estrogens and selective estrogen receptor modulators (SERMs) play in this process (mainly utilizing journal reports and reviews from the last four years).”
    • Various factors affect skin aging and the maintenance of dermal health including internal or external factors and the microbiome.
    • Estrogens exert important anti-aging effects on skin and contribute to dermal health. Skin collagen and elastin composition is tied to 17β-estradiol levels during aging and menopause.
    • The authors stress that isoflavonoid compounds are not endocrine disruptors. Instead, they are SERMs that improve dermal health.
    • In patients, with estrogen-sensitive cancers, it’s important to limit the extracutaneous effects of SERMs. A new formulation involves the active agent only delivering treatment to the dermal layers, with inactivation once it reaches the blood. An example of such an agent is the estrogen analog methyl estradiol propanoate (MEP).