Interpretation: Young, previously healthy, individuals largely recover from SARS-CoV-2 infection. However, the constellation of higher BMI, dyslipidaemia, and lower physical endurance 180 days after COVID-19 is suggestive of a higher risk of developing metabolic disorders and possible cardiovascular complications. These findings will guide...
Impact of Cannabis Use, Substance Use Disorders, and Psychiatric Diagnoses on COVID-19 Outcomes: A Retrospective Cohort Study - PubMed
Objective: While psychiatric disorders have been recognized as a risk factor for COVID-19 outcomes, the impact of substance use disorders (SUD) on COVID-19 outcomes has not, to date, been examined ..... see more
Conclusions: COVID-19 patients with SUD had greater likelihood of requiring critical interventions, such as ICU admission and ventilatory support. SUD and psychiatric diagnoses were also associated with a longer duration of hospitalization and greater number of hospital admissions. These findings identify COVID-19 patients with SUD and...
OU Research Study Finds Connection Between Symptomatic COVID-19 Infection and Impaired Pain Modulation
Christopher D. Black, Ph.D., associate professor in the Department of Health and Exercise Science, Dodge Family College of Arts and Sciences, led the study. A study led by researchers at ..... see more
A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severity - Nature Communications
A subset of patients has long-lasting symptoms after mild to moderate Coronavirus disease 2019 (COVID-19). In a prospective observational cohort study, we analyze clinical and laboratory parameters in 42 post-COVID-19 ..... see more
Association of hand grip strength with hemoglobin, interleukin 8 and C-reactive protein in post-COVID-19 syndrome/non-myalgic encephalomyelitis/chronic fatigue syndrome and with hemoglobin, N-terminal prohormone of brain natriuretic peptide, bilirubin, and ferritin in post-COVID-19 syndrome/myalgic encephalomyelitis/chronic fatigue syndrome may...
Rebound Phenomenon after Nirmatrelvir/Ritonavir Treatment of Coronavirus Disease-2019 in High-Risk Persons
ABSTRACT. In a cohort of 483 high-risk patients treated with nirmatrelvir/ritonavir for coronavirus disease-2019, two patients (0.4%) required hospitalization b see more
Source : https://doi.org/10.1093/cid/ciac481
In a cohort of 483 high-risk patients treated with nirmatrelvir/ritonavir for coronavirus disease-2019, two patients (0.4%) required hospitalization by day 30. Four patients (0.8%) experienced rebound of symptoms, which were generally mild, at median of 9 days after treatment, and all resolved without additional COVID-19-directed therapy.
Nirmatrelvir Use and Severe Covid-19 Outcomes during the Omicron Surge
The oral protease inhibitor nirmatrelvir has shown substantial efficacy in high-risk, unvaccinated patients infected with the B.1.617.2 (delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Data regarding the ..... see more
Source : https://www.nejm.org/doi/full/10.1056/NEJMoa2204919
ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19 - Nature Communications
Genetic factors have been found to be associated with severe COVID-19. Here, the authors integrated genomic, proteomic, and single-cell data to identify ELF5 as a candidate risk gene with a ..... see more
The transcription factor ELF5 (ELF5) shows robust and directionally consistent associations across different outcome definitions, including a >4-fold higher risk (odds ratio: 4.88; 95%-CI: 2.47–9.63; p-value < 5.0 × 10−6) for severe COVID-19 per 1 s.d. higher genetically predicted plasma ELF5. We show that ELF5 is specifically expressed in epithelial cells of the respiratory system, such as secretory and alveolar type 2 cells, using single-cell RNA sequencing and immunohistochemistry. These cells are also likely targets of SARS-CoV-2 by colocalisation with key host factors, including ACE2 and TMPRSS2. In summary, large-scale human genetic studies together with gene expression at single-cell resolution highlight ELF5 as a risk gene for severe COVID-19, supporting a role of epithelial cells of the respiratory system in the adverse host response to SARS-CoV-2.
Mechanism behind deadly fungal infection on top of influenza or Covid-19 deciphered
Over 15 per cent of all critically ill patients who end up in intensive care with severe influenza or Covid-19 additionally develop aspergillosis, a pulmonary fungal infection. This doubles their ..... see more
“In tissue stainings, we also saw that the corona or influenza virus affects the epithelium of the lungs. This is the layer of cells that lines the respiratory tract and lung tissue, which forms the first barrier against infections. For Covid-19, we were able to show that specifically in the locations where the virus affects the epithelium,...
A simple surgical mask modification to pass N95 respirator-equivalent fit testing standards during the COVID-19 pandemic
Background The COVID-19 pandemic has infected hundreds of millions of people resulting in millions of deaths worldwide. While N95 respirators remain the gold standard as personal protective equipment, they are ..... see more
Conclusions: Rubber bands, a low-cost and easily-accessible modification, can improve the seal and protective ability of a standard surgical mask to the level of an N95 respirator. This could mitigate N95 respirator shortages worldwide and provide individuals in under-resourced regions a practical means for increased personal respiratory...
Neurographic Evidence of Inflammatory Polyneuropathies in Peri-COVID-19 Circumstances and Their Relationship With Acute Disease Severity and Inflammatory Storm
Published: March 26, 2022 DOI: 10.7759/cureus.23517 Cite this article as: Hasrat N H, Kadhum H J, Hashim A R, et al. (March 26, 2022) Neurographic Evidence of Inflammatory Polyneuropathies in ..... see more
The majority of the inflammatory polyneuropathy (44.4%) was diagnosed four to 12 weeks after the COVID-19 infection, with GBS being the most common type (72.2% of cases). Moreover, the nerve conduction velocity, the distal latency, and the amplitude of the most studied nerves were slower, more prolonged, and lower, respectively, among the...
COVID-19 Vaccine Cardiac Complications: A Case Series on Implications of Marijuana in Adolescents With Myopericarditis
Monitoring Editor: Alexander Muacevic and John R Adler We report on two critically ill pediatric patients, aged 16 and 18 years, presenting with acute myopericarditis at a tertiary-care center in ..... see more
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156396/
Hyperglycemia in Severe and Critical COVID-19 Patients: Risk Factors and Outcomes
Published: August 02, 2022 DOI: 10.7759/cureus.27611 Cite this article as: Le V, Ha Q, Tran M, et al. (August 02, 2022) Hyperglycemia in Severe and Critical COVID-19 Patients: Risk Factors ..... see more
A Novel Non-invasive Index of Cardiopulmonary Reserve for the Prediction of Failure of Weaning From Mechanical Ventilation
Published: July 22, 2022 DOI: 10.7759/cureus.27150 Cite this article as: Nikitas G T, Kykalos S, Ntikoudi E, et al. (July 22, 2022) A Novel Non-invasive Index of Cardiopulmonary Reserve for ..... see more
A Review of the Recent Monkeypox Outbreak in 2022
Published: August 11, 2022 DOI: 10.7759/cureus.27880 Cite this article as: Al-Gburi S, Namuq Z (August 11, 2022) A Review of the Recent Monkeypox Outbreak in 2022. Cureus 14(8): e27880. doi:10.7759/cureus.27880 ..... see more
Source : https://www.cureus.com/articles/108076-a-review-of-the-recent-monkeypox-outbreak-in-2022/metrics
Our results showed that antibody titers increased 8-fold after the booster dose. We believe that the administration of the mRNA vaccine as a booster dose can provide more effective protection against COVID-19 infection, especially in individuals with risk factors.
The impact of HMG-CoA reductase inhibitors use on the clinical outcomes in critically ill patients with COVID-19: A multicenter, cohort study
BackgroundThe cardiovascular complications of Coronavirus Disease 2019 (COVID-19) may be attributed to the hyperinflammatory state leading to increased mortality in patients with COVID-19. HMG-CoA Reductase Inhibitors (statins) are known to ..... see more
The Efficacy of Bezlotoxumab in the Prevention of Recurrent Clostridium difficile: A Systematic Review
Published: August 13, 2022 DOI: 10.7759/cureus.27979 Cite this article as: Thandavaram A, Channar A, Purohit A, et al. (August 13, 2022) The Efficacy of Bezlotoxumab in the Prevention of Recurrent ..... see more
LFAs have the potential to assist in early identification of seronegative patients who may demonstrate the greatest benefit from monoclonal antibody treatment.
Architecture and self-assembly of the jumbo bacteriophage nuclear shell - Nature
Bacteria encode myriad defences that target the genomes of infecting bacteriophage, including restriction-modification and CRISPR-Cas systems1. In response, one family of large bacteriophages uses a nucleus-like compartment to protect its ..... see more
Viral escape at prevalent T-cell epitopes restricted by high frequency HLA may be particularly problematic when vaccine immunity is focussed on a single protein such as SARS-CoV-2 Spike and provides a strong argument for inclusion of multiple viral proteins in next generation vaccines and highlights the urgent need for monitoring T-cell escape...