Skip to main content
micro-community-banner
 
  • Saved

made a Post



Conclusions: COVID-19 is strongly associated with the risk of incident diabetes, including both type 1 and type 2 diabetes. We should be aware of the risk of developing diabetes after COVID-19 and prepare for the associated health problems, given the large and growing number of people infected with COVID-19. However, the body of evidence...

  • Saved

made a Post



Conclusions: The matched cohort analysis found an increased risk for the composite outcome after the second dose; however, the SCCS analysis showed no increased risk. Considering that the SCCS can cancel out time-invariant confounders, the current results suggest that COVID-19 vaccination is unlikely to causally increase the risk of ocular...

  • Saved

made a Post

Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

Author summary The COVID-19 pandemic has ignited efforts to repurpose existing drugs as safe and effective antivirals. Rather than directly inhibiting viral enzymes, host-targeted antivirals inhibit host cell processes to ..... see more

Source : https://doi.org/10.1371/journal.ppat.1010832



Overall, these findings suggest that small GTPases are promising targets for host-targeted antivirals.

  • Saved

made a Post

A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes - PubMed

Seasonal influenza vaccines offer little protection against pandemic influenza virus strains. It is difficult to create effective prepandemic vaccines because it is uncertain which influenza virus subtype will cause the ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36423275/



Our studies indicate that mRNA vaccines can provide protection against antigenically variable viruses by simultaneously inducing antibodies against multiple antigens.

  • Saved

made a Post



Highlights


  • Reliable detection of SARS-CoV-2 RNA with both the cobas®6800 and NeuMoDx™ SARS-CoV-2 assays.
  • Highest sensitivity of SARS-CoV-2 RNA detection in hospitalized symptomatic patients in nasopharyngeal swabs.
  • SARS-CoV-2 viral load in anterior nasal swabs comparable to throat swabs.
  • High false negative rate of SARS-CoV-2 in...

  • Saved

made a Post



Interpretation: Previous natural infection was associated with lower incidence of SARS-CoV-2 infection, regardless of the variant, than mRNA primary-series vaccination. Vaccination remains the safest and most optimal tool for protecting against infection and COVID-19-related hospitalisation and death, irrespective of previous infection...

  • Saved

made a Post



Interpretation: Our data showed the immunological signature of monkeypox virus infection, characterised by an early expansion of activated effector CD4 and CD8 T cells that persisted over time. Almost all patients, even regardless of HIV infection, developed a poxvirus-specific Th1 cell response. These results might have implications on the...

  • Saved

made a Post

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner

Tina Schumann, Santiago Costas Ramon, Nadja Schubert, Mohamad Aref Mayo, Melanie Hega, Katharina Isabell Maser, Servi-Remzi Ada, Lukas Sydow, Mona Hajikazemi, Markus Badstübner, Patrick Müller, Yan Ge, Farhad Shakeri, Andreas ..... see more

Source : https://rupress.org/jem/article-abstract/220/1/e20220829/213670/Deficiency-for-SAMHD1-activates-MDA5-in-a-cGAS?redirectedFrom=fulltext#:~:text=https://doi.org/10.1084/jem.20220829



Our work positions cGAS/STING upstream of tonic IFN signaling in Samhd1-deficient mice and highlights an important role of the pathway in physiological and pathophysiological innate immune priming.

  • Saved

made a Post

Correlation Between HbA1c Levels and Mortality Rates in Hospitalized COVID-19 Patients

Objective Throughout the coronavirus disease 2019 (COVID-19) pandemic, multiple factors have been associated with poor prognosis for those infected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Age, ..... see more

Source : https://www.cureus.com/articles/120300-correlation-between-hba1c-levels-and-mortality-rates-in-hospitalized-covid-19-patients



Conclusion: In this study, we show that HbA1c levels, regardless of concurrent comorbidities, are unlikely to be correlated to mortality rates among hospitalized COVID-19 patients. HbA1c levels should not be used as a marker for whether these patients should be admitted to the hospital for further inpatient management or discharged from the...

  • Saved

made a Post



Conclusions and Relevance: This study suggests that long COVID is prevalent and associated with female gender and older age, while risk may be diminished by completion of primary vaccination series prior to infection.

  • Saved

made a Post

Comparative risk of thrombosis with thrombocytopenia syndrome or thromboembolic events associated with different covid-19 vaccines: international network cohort study from five European countries and the US

Objective To quantify the comparative risk of thrombosis with thrombocytopenia syndrome or thromboembolic events associated with use of adenovirus based covid-19 vaccines versus mRNA based covid-19 vaccines. Design International network ..... see more

Source : https://www.bmj.com/content/379/bmj-2022-071594



Conclusions: In this multinational study, a pooled 30% increased risk of thrombocytopenia after a first dose of the ChAdOx1-S vaccine was observed, as was a trend towards an increased risk of venous thrombosis with thrombocytopenia syndrome after Ad26.COV2.S compared with BNT162b2. Although rare, the observed risks after adenovirus based...

  • Saved

made a Post

COVID-19 and systemic lupus erythematosus genetics: A balance between autoimmune disease risk and protection against infection

Author summary We observed a correlation between the genetic associations with severe COVID-19 and those with systemic lupus erythematosus (SLE, Lupus), and aimed to discover which genetic loci were shared ..... see more

Source : https://doi.org/10.1371/journal.pgen.1010253



Our analyses suggest that several loci with reciprocal effects between the two traits have a role in the defense response pathway, adding to the evidence that SLE risk alleles are protective against infection.

  • Saved

made a Post

Gastrointestinal Bleeding Induced by Immunoglobulin A Vasculitis on Post-Mild COVID-19 Patients

We describe the case of a 51-year-old man who presented with a palpable purpuric rash and associated four days of lower gastrointestinal bleeding one month after testing positive for COVID-19. ..... see more

Source : https://www.cureus.com/articles/118373-gastrointestinal-bleeding-induced-by-immunoglobulin-a-vasculitis-on-post-mild-covid-19-patients



An abdominal computed tomography scan showed distal ileitis, and a skin biopsy was significant for IgA vasculitis. Treatment with methylprednisolone was started, which led to the resolution of symptoms. Immunologic consequences of COVID-19 must not be overlooked, as they have a wide variety of presentations in diverse aged populations. IgA...

  • Saved

made a Post

All That We Need to Know About the Current and Past Outbreaks of Monkeypox: A Narrative Review

Monkeypox is a rare, zoonotic viral illness that was initially endemic mainly to Africa. The virus later spread to non-African countries and, in 2022, it exploded on a global scale, ..... see more

Source : https://www.cureus.com/articles/122177-all-that-we-need-to-know-about-the-current-and-past-outbreaks-of-monkeypox-a-narrative-review



This narrative review aims to summarize the evolution in the epidemiology, clinical features, mode of transmission, and management protocol of human monkeypox infection (H-MPVX) over the decades.

  • Saved

made a Post

The association between vaccination status identification and societal polarization - Nature Human Behaviour

Public discord between those vaccinated and those unvaccinated for COVID-19 has intensified globally. Theories of intergroup relations propose that identifying with one's social group plays a key role in the ..... see more

Source : https://www.nature.com/articles/s41562-022-01469-6



The findings confirm that vaccination status identification (VSI) explains substantial variance in a range of polarizing attitudes and behaviours. VSI was also related to higher psychological reactance toward mandatory vaccination policies among the unvaccinated. Higher levels of VSI reduced the gap between intended and actual...

  • Saved

made a Post

Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative

Author summary COVID-19 clinical outcomes vary immensely, but a patient's genetic make-up is an important determinant of how they will fare against the virus. While many genetic variants commonly found ..... see more

Source : https://doi.org/10.1371/journal.pgen.1010367



These results further support TLR7 as a genetic determinant of severe disease and suggest that larger studies on rare variants influencing COVID-19 outcomes could provide additional insights.

  • Saved

made a Post

Comparative risk of thrombosis with thrombocytopenia syndrome or thromboembolic events associated with different covid-19 vaccines: international network cohort study from five European countries and the US

Objective To quantify the comparative risk of thrombosis with thrombocytopenia syndrome or thromboembolic events associated with use of adenovirus based covid-19 vaccines versus mRNA based covid-19 vaccines. Design International network ..... see more

Source : https://www.bmj.com/content/379/bmj-2022-071594



Conclusion: In this multinational study, a pooled 30% increased risk of thrombocytopenia after a first dose of the ChAdOx1-S vaccine was observed, as was a trend towards an increased risk of venous thrombosis with thrombocytopenia syndrome after Ad26.COV2.S compared with BNT162b2. Although rare, the observed risks after adenovirus based...

  • Saved

made a Post



Conclusions and Relevance: This study presents modeled estimates of the proportion of individuals with at least 1 of 3 self-reported Long COVID symptom clusters (persistent fatigue with bodily pain or mood swings; cognitive problems; or ongoing respiratory problems) 3 months after symptomatic SARS-CoV-2 infection.


  • Saved

made a Post

Inspiratory muscle training enhances recovery post-COVID-19: a randomised controlled trial - PubMed

IMT may represent an important home-based rehabilitation strategy for wider implementation as part of COVID-19 rehabilitative strategies. Given the diverse nature of long COVID, further research is warranted on the ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35236727/



Conclusions: IMT may represent an important home-based rehabilitation strategy for wider implementation as part of COVID-19 rehabilitative strategies. Given the diverse nature of long COVID, further research is warranted on the individual responses to rehabilitation; the withdrawal rate herein highlights that no one strategy is likely to be...

  • Saved

made a Post

Coinfection by influenza A virus and respiratory syncytial virus produces hybrid virus particles - Nature Microbiology

Interactions between respiratory viruses during infection affect transmission dynamics and clinical outcomes. To identify and characterize virus-virus interactions at the cellular level, we coinfected human lung cells with influenza A ..... see more

Source : https://www.nature.com/articles/s41564-022-01242-5



Our observations define a previously unknown interaction between respiratory viruses that might affect virus pathogenesis by expanding virus tropism and enabling immune evasion.