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Severity and prognostic factors of SARS-CoV-2-induced pneumonia: the value of clinical and laboratory biomarkers and the A-DROP score

Introduction. Numerous clinical and laboratory scores that include C-reactive protein (CRP), D-dimer, ferritin, lactate dehydrogenase (LDH), interleukin 6 (IL-6), procalcitonin (PCT), blood urea nitrogen (BUN), creatinine levels and oxygenation (PaO2 ..... see more

Source : https://www.researchsquare.com/article/rs-1542245/v1


Conclusions: Numerous laboratory biomarkers in addition to obesity, dizziness at the time of admission and the history of hypertension may predict the need for ICU admission and ventilation, as well as mortality in COVID-19. Moreover, A-DROP may be a suitable scoring system for the assessment of general health and disease outcome in COVID-19.

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Sex-disaggregated differences for COVID-19 sequelae and long COVID syndrome were observed. Few COVID-19 studies report sex-disaggregated data, underscoring the need for further sex-based research/reporting of COVID-19 disease.

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Viral dynamics of Omicron and Delta SARS-CoV-2 variants with implications for timing of release from isolation: a longitudinal cohort study

AbstractBackground. In January 2022, United States guidelines shifted to recommend isolation for 5 days from symptom onset, followed by 5 days of mask wearing. see more

Source : https://doi.org/10.1093/cid/ciac510


Conclusions: The majority of our Delta- and Omicron-infected cohort culture-converted by day 6, with no further impact of booster vaccination on sterilization or cycle threshold decay. We found that rapid antigen testing may provide reassurance of lack of infectiousness, though guidance to mask for days 6-10 is supported by our finding that 17%...

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Conclusion: The findings revealed that out of 10 antibiotics, nitrite-positive groups demonstrated higher resistance only against ceftriaxone, cefuroxime, cefotaxime, and doxycycline. Other antibiotics showed no statistically significant differences in resistance. Furthermore, the highest relative resistance rate was recorded against...

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Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2 - PubMed

Among persons who had been previously infected with SARS-CoV-2 (regardless of whether they had received any dose of vaccine or whether they had received one dose before or after infection), ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35613036/


Conclusions: Among persons who had been previously infected with SARS-CoV-2 (regardless of whether they had received any dose of vaccine or whether they had received one dose before or after infection), protection against reinfection decreased as the time increased since the last immunity-conferring event; however, this protection was higher...

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Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2 - PubMed

Among persons who had been previously infected with SARS-CoV-2 (regardless of whether they had received any dose of vaccine or whether they had received one dose before or after infection), ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35613036/

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Conclusion: T1 morphology has a modest sensitivity with specificity and positive predictive value amongst S. aureus for identification of methicillin resistance at 48 hours. It can be potentially used for the identification of MRSA, especially in resource-limited settings and wherein a molecular test is not repeated if PCR testing has already...

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While other studies have shown benefit from vitamin D in COVID,10 the NIH states insufficient evidence either for or against the use of Vitamin D in COVID.11 I think it is reasonable to give a high dose once in this setting; however, I do not advocate intermittent high-dose vitamin D because of increased risk of fracture and falls.12,13 I do...

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Radiological Finding of Crazy-Paving Pattern in COVID-19 Pneumonia

The recent global pandemic of coronavirus disease 2019 (COVID-19) has brought many radiographic findings in other respiratory disease processes. One of these radiological findings is crazy paving. This paper discusses ..... see more

Source : https://www.cureus.com/articles/100573-radiological-finding-of-crazy-paving-pattern-in-covid-19-pneumonia/



Chest CT showed ground-glass opacities and interlobular septal thickening consistent with a crazy-paving appearance. As part of the common CT findings of patients with active COVID-19 infection, crazy paving should prompt the interpreting radiologist to consider COVID-19 pneumonia as part of the differential.

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Blood and saliva SARS-CoV-2 antibody levels in self-collected dried spot samples - Medical Microbiology and Immunology

We examined the usefulness of dried spot blood and saliva samples in SARS-CoV-2 antibody analyses. We analyzed 1231 self-collected dried spot blood and saliva samples from healthcare workers. Participants filled ..... see more

Source : https://link.springer.com/article/10.1007/s00430-022-00740-x



Self-collected dry blood and saliva spot samples combined with the GSP/DELFIA technique comprise a valuable tool to investigate an individual’s immune response to SARS-CoV-2 exposure or vaccination. Saliva IgG has high potential to monitor vaccination response wane, since the sample is non-invasive and easy to collect.

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Seasonal coronavirus protective immunity is short-lasting - Nature Medicine

The durability of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unknown. Lessons from seasonal coronavirus infections in humans show that reinfections can occur within 12 months of ..... see more

Source : https://www.nature.com/articles/s41591-020-1083-1



Insights from infections with the four seasonal human coronaviruses might reveal common characteristics applicable to all human coronaviruses. We monitored healthy individuals for more than 35 years and determined that reinfection with the same seasonal coronavirus occurred frequently at 12 months after infection.

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Interpretation: ChAdOx1 nCoV-19 is well tolerated and immunogenic in children aged 6–17 years, inducing concentrations of antibody that are similar to those associated with high efficacy in phase 3 studies in adults. No safety concerns were raised in this trial.

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Interpretation: COVID-19 deaths and hospital admissions were higher in people with immune-mediated inflammatory diseases. We saw no increased risk of adverse COVID-19 outcomes in those on most targeted immune-modifying drugs for immune-mediated inflammatory diseases compared with those on standard systemic therapy.

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Interpretation: The ability of high-throughput serological assays to predict neutralising antibody titres is likely to be crucial for evaluation of immunity at the population scale. These data can facilitate the selection of the most suitable assays as surrogates of functional neutralising activity and suggest that such measurements might be...

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Intradermal Testing With COVID-19 mRNA Vaccines Predicts Tolerance

BackgroundThe newly developed mRNA-based COVID-19 vaccines can provoke anaphylaxis, possibly induced by polyethylene glycol (PEG) contained in the vaccine. The management of persons with a history of PEG allergy or ..... see more

Source : https://doi.org/10.3389/falgy.2022.818049


Conclusion: Sensitization to SARS-CoV-2 mRNA vaccines can be detected with intradermal testing. Significantly more individuals were sensitized to mRNA vaccines in the post-vaccination cohort. A two-step 10–90%-vaccination protocol can be safely administered upon negative skin testing.

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Food allergy is associated with lower risk of SARS-CoV-2 infection

NIH study finds high BMI and obesity raise infection risk, but asthma does not. A National Institutes of Health-funded study has found that people with food allergies are less likely ..... see more

Source : https://www.nih.gov/news-events/news-releases/food-allergy-associated-lower-risk-sars-cov-2-infection



NIH study finds high BMI and obesity raise infection risk, but asthma does not.

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Allergological study in patients vaccinated against COVID-19 with suspected allergic reactions - Allergy, Asthma & Clinical Immunology

Background One of the main barriers to vaccination against SARS-CoV-2 is the fear of developing hypersensitivity reactions to any of its components. Although these reactions are very rare, it is ..... see more

Source : https://aacijournal.biomedcentral.com/articles/10.1186/s13223-022-00685-z



Conclusions: Thanks to the allergological and immunohistochemical study, the vaccination protocol could be completed in about half of the patients who presented suspected hypersensitivity reactions to SARS-CoV-2 vaccines. IDTs with vaccines could be a valuable method for assessing the immunogenicity of the vaccines.

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Asthma Outcome Measures Before and After the COVID-19 Outbreak Among the Pediatric Population in a Community Hospital

Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is a global health threat that has affected patient care enormously. Moderate to severe asthma was listed as a risk ..... see more

Source : https://www.cureus.com/articles/100236-asthma-outcome-measures-before-and-after-the-covid-19-outbreak-among-the-pediatric-population-in-a-community-hospital



Conclusion: Among a majority African American pediatric population, there were significant improvements in asthma outcomes after COVID-19 societal changes when compared to before COVID-19 based on outcome variables.

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Brain motor and fear circuits regulate leukocytes during acute stress - Nature

The nervous and immune systems are intricately linked1. Although psychological stress is known to modulate immune function, mechanistic pathways linking stress networks in the brain to peripheral leukocytes remain poorly ..... see more

Source : https://www.nature.com/articles/s41586-022-04890-z



Collectively, these data show that distinct brain regions differentially and rapidly tailor the leukocyte landscape during psychological stress, thus calibrating the immune system’s capacity to respond to physical threats.

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Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: Update of a living systematic review and meta-analysis

Diana Buitrago-Garcia, Aziz Mert Ipekci, Leonie Heron, Hira Imeri, Lucia Araujo-Chaveron, Ingrid Arevalo-Rodriguez, Agustín Ciapponi, Muge Cevik, Anthony Hauser, Muhammad Irfanul Alam Subject Areas For more information about PLOS Subject ..... see more

Source : https://doi.org/10.1371/journal.pmed.1003987



Conclusions: Based on studies published up to July 2021, most SARS-CoV-2 infections were not persistently asymptomatic, and asymptomatic infections were less infectious than symptomatic infections. Summary estimates from meta-analysis may be misleading when variability between studies is extreme and prediction intervals should be presented....