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Conclusions and Relevance: The findings of this study suggest that preinfection psychological distress may be a risk factor for post–COVID-19 conditions in individuals with SARS-CoV-2 infection. Future work should examine the biobehavioral mechanism linking psychological distress with persistent postinfection symptoms.

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Study Finds No Benefit to Taking Fluvoxamine for COVID-19 Symptoms

Newswise - DURHAM, N.C. - A study led by the Duke Clinical Research Institute (DCRI) in partnership with Vanderbilt University found no symptomatic or clinical benefit to taking the antidepressant ..... see more

Source : https://www.newswise.com/coronavirus/study-finds-no-benefit-to-taking-fluvoxamine-for-covid-19-symptoms


“Other research suggests that 100 mg of fluvoxamine taken twice daily may be effective in treating COVID-19, but tolerance may be a limitation,” said Susanna Naggie, M.D., the DCRI principal investigator overseeing the study’s clinical coordinating center. “We set out to test if 50 mg taken twice daily is effective and tolerated. We...

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Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severity

We began by assessing the presence of immunoglobulin G (IgG) antibodies against AngII in the plasma of 221 subjects, among which 115 were hospitalized patients with COVID-19, 58 were control ..... see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544317/


Here, we show that a significant proportion of hospitalized patients with COVID-19 developed autoantibodies against AngII, whose presence correlates with lower blood oxygenation, blood pressure dysregulation, and overall higher disease severity. Anti-AngII antibodies can develop upon specific immune reaction to the SARS-CoV-2 proteins Spike or...

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Regular use of common cholesterol-lowering drug linked to reduction of COVID-19 severity, risk of death

NEW ORLEANS - Commonly used cholesterol-lowering statins may reduce the risk of death and severity of COVID-19 disease, suggests a study of more than 38,000 patients being presented at the ..... see more

Source : https://www.newswise.com/coronavirus/regular-use-of-common-cholesterol-lowering-drug-linked-to-reduction-of-covid-19-severity-risk-of-death/?article_id=780011


“This research illustrates the importance of evaluating medications that could be repurposed to help patients in ways other than their intended use,” said Dr. Crimi. “Our results suggest statins could be an additional cost-effective solution against COVID-19 disease severity and should be studied further.”

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Meaning: The results of this study suggest that ambulatory patients with COVID-19, either vaccinated or not, present a clinically relevant increased risk of incident VTE during the acute phase, with the risk pronounced by factors of older age, male sex, obesity, incomplete vaccination, and factor V Leiden thrombophilia.

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Neurogenesis is disrupted in human hippocampal progenitor cells upon exposure to serum samples from hospitalized COVID-19 patients with neurological symptoms - Molecular Psychiatry

Coronavirus disease 2019 (COVID-19), represents an enormous new threat to our healthcare system and particularly to the health of older adults. Although the respiratory symptoms of COVID-19 are well recognized, ..... see more

Source : https://www.nature.com/articles/s41380-022-01741-1


Overall, our results show that serum from COVID-19 patients with delirium can negatively affect hippocampal-dependent neurogenic processes, and that this effect is mediated by IL6-induced production of the downstream inflammatory cytokines IL12 and IL13, which are ultimately responsible for the detrimental cellular outcomes.

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Regular Use of Ivermectin as Prophylaxis for COVID-19 Led Up to a 92% Reduction in COVID-19 Mortality Rate in a Dose-Response Manner: Results of a Prospective Observational Study of a Strictly Controlled Population of 88,012 Subjects

Monitoring Editor: Alexander Muacevic and John R Adler Background We have previously demonstrated that ivermectin used as prophylaxis for coronavirus disease 2019 (COVID-19), irrespective of the regularity, in a strictly ..... see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525042/


Conclusion: Non-use of ivermectin was associated with a 12.5-fold increase in mortality rate and a seven-fold increased risk of dying from COVID-19 compared to the regular use of ivermectin. This dose-response efficacy reinforces the prophylactic effects of ivermectin against COVID-19.

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Meaning: This study found that the humoral response after the third vaccine dose was sustained for 5 months and that antibody kinetics were associated with Omicron infection.

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Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection - Nature Medicine

SARS-CoV-2 vaccine immunogenicity varies between individuals, and immune responses correlate with vaccine efficacy. Using data from 1,076 participants enrolled in ChAdOx1 nCov-19 vaccine efficacy trials in the United Kingdom, we ..... see more

Source : https://www.nature.com/articles/s41591-022-02078-6


Our results demonstrate association of HLA type with COVID-19 vaccine antibody response and risk of breakthrough infection, with implications for future vaccine design and implementation.

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Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against Omicron in Brazil - Nature Communications

This study investigates the effectiveness of COVID-19 vaccine boosters following a primary series of CoronaVac vaccination. Using data from Brazil during the Omicron wave, the authors show that boosters provided ..... see more

Source : https://www.nature.com/articles/s41467-022-33169-0


Waning against severe Covid-19 after 120 days was only observed after a homologous booster. Heterologous booster might be preferable to individuals with completed primary series inactivated vaccine.

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Long-term cardiac pathology in individuals with mild initial COVID-19 illness - Nature Medicine

Cardiac symptoms are increasingly recognized as late complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in previously well individuals with mild initial illness, but the underlying pathophysiology leading ..... see more

Source : https://www.nature.com/articles/s41591-022-02000-0


Ongoing inflammatory cardiac involvement may, at least in part, explain the lingering cardiac symptoms in previously well individuals with mild initial COVID-19 illness.

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Clinical, Virologic, and Immunologic Evaluation of Symptomatic Coronavirus Disease 2019 Rebound Following Nirmatrelvir/Ritonavir Treatment - PubMed

Nirmatrelvir/ritonavir treatment does not impede adaptive immune responses to SARS-CoV-2. Clinical rebound corresponds to development of a robust antibody and T-cell immune response, arguing against a high risk of disease ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36200701/


Conclusions: Nirmatrelvir/ritonavir treatment does not impede adaptive immune responses to SARS-CoV-2. Clinical rebound corresponds to development of a robust antibody and T-cell immune response, arguing against a high risk of disease progression. The presence of infectious virus supports the need for isolation and assessment of longer...

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Significance: Using absolute quantification of both cytokines and metabolites from the plasmas of convalescent COVID-19 patients, machine-learning approaches identified that a combination of cytokines and metabolites can clearly discriminate convalescent patients with rapidly faded antibodies (CO) from ordinary convalescents with antibodies...

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Evolution of Mood Symptomatology Through the COVID-19 Pandemic: Findings From the CovidSense Longitudinal Study

Background The severe acute respiratory syndrome coronavirus 2 global pandemic, with its associated coronavirus disease 2019 (COVID-19) illness, has led to significant mental, physical, social, and economic hardships. Physical distancing, ..... see more

Source : https://www.cureus.com/articles/109152-evolution-of-mood-symptomatology-through-the-covid-19-pandemic-findings-from-the-covidsense-longitudinal-study


Conclusions:The effects of pandemic-related chronic stress were predominant in young adults and individuals with pre-existing mental and medical conditions regardless of whether they had acquired COVID-19 or not. These results point to the possibility of allocating preventive as well as treatment resources based on vulnerability.

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SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression

Rina Hashimoto, Formal analysis, Investigation, Methodology, Validation, Writing - original draft, 1 , † Junya Takahashi, Formal analysis, Investigation, Validation, Visualization, Writing - original draft, Writing - review & editing, ..... see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491726/


We concluded that the down-regulation of CLDN5 expression is a pivotal mechanism for SARS-CoV-2–induced endothelial barrier disruption in respiratory organs and that inducing CLDN5 expression is a therapeutic strategy against COVID-19.

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Test predicts which COVID-19 patients will grow worse, Stanford Medicine study find

Elevated virus levels in hospitalized COVID-19 patients' blood predicts worsening respiratory symptoms and suggests ongoing viral replication in later disease stages, Stanford Medicine-led study says. - By Krista Conger A ..... see more

Source : https://med.stanford.edu/news/all-news/2022/09/high-levels-of-covid-19-virus-in-hospitalized-patients--blood-pr.html


The test measures patient blood levels of a protein on the virus that causes COVID-19. High levels of the protein correlated strongly with an increased need for respiratory support five days later, regardless of the patient’s disease severity when the test was conducted, the researchers found. People whose levels were high were also likely to...

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Role for N-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 Spike maturation and viral infectivity - PubMed

Functional and epidemiological data suggest that N -linked glycans on the SARS-CoV-2 Spike protein may contribute to viral infectivity. To investigate this, we created a panel of N-to-Q mutations at ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36149962/


In contrast, glycan mutations had a relatively minor effect on cell surface expression of Spike, ACE2 binding, and syncytia formation. A similar dichotomy in function was observed when virus was produced in host cells lacking ER chaperones, calnexin and calreticulin. Here, while both chaperones regulated pseudovirus function, only VLPs produced...

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COVID-19 and Genitourinary Tract: A Retrospective Study in the Tertiary Care Center

Monitoring Editor: Alexander Muacevic and John R Adler Introduction COVID-19 pandemic has spread across the globe in the last two years and COVID-19 pneumonia is its typical presentation. Coronavirus (SARS-CoV-2) ..... see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393072/


Conclusions: COVID-19 patients do have the chance of developing the involvement of the urinary tract and male genital system and the clinicians should be aware of this so that they can manage these patients accordingly.

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Study Suggests Moral Values Predict Regional Differences in COVID-19 Vaccination Rates

A new study suggests that moral values and beliefs have a significant impact on regional disparities in vaccination rates, according to investigators from the University of Southern California who published ..... see more

Source : https://www.pharmacytimes.com/view/study-suggests-moral-values-predict-regional-differences-in-covid-19-vaccination-rates


“The loyalty finding is quite surprising because there is a lot of rhetoric about anti-vaccination among conservatives. However, what we’re showing is that typical conservatives do not tend to be anti-vaxxers,” said co-author Morteza Dehghani, PhD, in the press release. “The anti-vaxxers tend to be not high on loyalty, but high on...

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Severe COVID-19 caused by "senile" interferon response in older patients, researchers suggest

Researchers in Germany have discovered that age-dependent impairments in antiviral interferon proteins underlie the increased susceptibility of older patients to severe COVID-19. The study, published today in the Journal of ..... see more

Source : https://www.eurekalert.org/news-releases/965491


“Collectively, our data suggest that impaired type I IFN signaling in combination with impaired IFN-γ–mediated immune responses can account for the observed high SARS-CoV-2 disease susceptibility of aged mice, and possibly older humans, too,” Schnepf says.