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Architecture and self-assembly of the jumbo bacteriophage nuclear shell - Nature

Architecture and self-assembly of the jumbo bacteriophage nuclear shell - Nature

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https://www.nature.com/articles/s41586-022-05013-4

Bacteria encode myriad defences that target the genomes of infecting bacteriophage, including restriction-modification and CRISPR-Cas systems1. In response, one family of large bacteriophages uses a nucleus-like compartment to protect its replicating genomes by excluding host defence factors2-4. However, the principal composition and structure of this compartment remain unknown.


The architecture and assembly dynamics of the chimallin shell suggest mechanisms for its nucleation and growth, and its role as a scaffold for phage-encoded factors mediating macromolecular transport, cytoskeletal interactions, and viral maturation.