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SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression

SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491726/

Rina Hashimoto, Formal analysis, Investigation, Methodology, Validation, Writing - original draft, 1 , † Junya Takahashi, Formal analysis, Investigation, Validation, Visualization, Writing - original draft, Writing - review & editing, 2 , † Keisuke Shirakura, Formal analysis, Investigation, Visualization, Writing - review & editing, 2 Risa Funatsu, Investigation, 2 Kaori


We concluded that the down-regulation of CLDN5 expression is a pivotal mechanism for SARS-CoV-2–induced endothelial barrier disruption in respiratory organs and that inducing CLDN5 expression is a therapeutic strategy against COVID-19.