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Coinfection by influenza A virus and respiratory syncytial virus produces hybrid virus particles - Nature Microbiology

Coinfection by influenza A virus and respiratory syncytial virus produces hybrid virus particles - Nature Microbiology

Source :

https://www.nature.com/articles/s41564-022-01242-5

Interactions between respiratory viruses during infection affect transmission dynamics and clinical outcomes. To identify and characterize virus-virus interactions at the cellular level, we coinfected human lung cells with influenza A virus (IAV) and respiratory syncytial virus (RSV). Super-resolution microscopy, live-cell imaging, scanning electron microscopy and cryo-electron tomography revealed extracellular and membrane-associated filamentous structures consistent with hybrid viral particles (HVPs).



Our observations define a previously unknown interaction between respiratory viruses that might affect virus pathogenesis by expanding virus tropism and enabling immune evasion.