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COVID-19 and systemic lupus erythematosus genetics: A balance between autoimmune disease risk and protection against infection

COVID-19 and systemic lupus erythematosus genetics: A balance between autoimmune disease risk and protection against infection

Source :

https://doi.org/10.1371/journal.pgen.1010253

Author summary We observed a correlation between the genetic associations with severe COVID-19 and those with systemic lupus erythematosus (SLE, Lupus), and aimed to discover which genetic loci were shared by these diseases and what biological processes were involved.



Our analyses suggest that several loci with reciprocal effects between the two traits have a role in the defense response pathway, adding to the evidence that SLE risk alleles are protective against infection.