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Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner

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https://rupress.org/jem/article-abstract/220/1/e20220829/213670/Deficiency-for-SAMHD1-activates-MDA5-in-a-cGAS?redirectedFrom=fulltext#:~:text=https://doi.org/10.1084/jem.20220829

Tina Schumann, Santiago Costas Ramon, Nadja Schubert, Mohamad Aref Mayo, Melanie Hega, Katharina Isabell Maser, Servi-Remzi Ada, Lukas Sydow, Mona Hajikazemi, Markus Badstübner, Patrick Müller, Yan Ge, Farhad Shakeri, Andreas Buness, Benjamin Rupf, Stefan Lienenklaus, Barbara Utess, Lina Muhandes, Michael Haase, Luise Rupp, Marc Schmitz, Thomas Gramberg, Nicolas Manel, Gunther Hartmann, Thomas Zillinger, Hiroki Kato, Stefan Bauer, Alexander Gerbaulet, Katrin Paeschke, Axel Roers, Rayk Behrendt; Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner.



Our work positions cGAS/STING upstream of tonic IFN signaling in Samhd1-deficient mice and highlights an important role of the pathway in physiological and pathophysiological innate immune priming.