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Reduced Muscle Strength Is Associated With Insulin Resistance in Type 2 Diabetes Patients With Osteoarthritis

Osteoarthritis, a leading cause of disability, is not only a consequence of aging and mechanical stress on cartilage, but is also associated with metabolic diseases ( 1, 2). Recent studies ..... see more

Source : https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgaa912/6056610?login=true

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Calcification of lower extremity arteries is related to the presence of osteoporosis in postmenopausal women with type 2 diabetes mellitus: a cross-sectional observational study

It is unknown whether there is any relationship between extremity arterial macroangiopathy and osteoporosis in type 2 diabetic mellitus (T2DM) patients. We provide evidence to show the association between lower ..... see more

Source : https://link.springer.com/article/10.1007/s00198-020-05775-5

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A novel economic framework to assess the cost-effectiveness of bone-forming agents in the prevention of fractures in patients with osteoporosis

A novel cost-effectiveness model framework was developed to incorporate the elevated fracture risk associated with a recent fracture and to allow sequential osteoporosis therapies to be evaluated. Treating patients with ..... see more

Source : https://link.springer.com/article/10.1007/s00198-020-05765-7

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Symptomatic aortitis at giant cell arteritis diagnosis: a prognostic factor of aortic event

Giant cell arteritis (GCA) is frequently associated with aortic involvement that is likely to cause life-threatening structural complications (aneurysm, dissection). Few studies have investigated the occurrence of these complications, and ..... see more

Source : https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-020-02396-5

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A Polygenic Score for Type 2 Diabetes Risk Is Associated With Both the Acute and Sustained Response to Sulfonylureas

There is a limited understanding of how genetic loci associated with glycemic traits and type 2 diabetes (T2D) influence the response to antidiabetic medications. Polygenic scores provide increasing power to ..... see more

Source : https://diabetes.diabetesjournals.org/content/70/1/293

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Depletion of Adipocyte Becn1 Leads to Lipodystrophy and Metabolic Dysregulation

Becn1 / Beclin-1 is a core component of the class III phosphatidylinositol 3-kinase required for autophagosome formation and vesicular trafficking. Although Becn1 has been implicated in numerous diseases such as ..... see more

Source : https://diabetes.diabetesjournals.org/content/70/1/182

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Advanced Liver Fibrosis Is Common in Patients With Type 2 Diabetes Followed in the Outpatient Setting: The Need for Systematic Screening

OBJECTIVE Assess the prevalence of nonalcoholic fatty liver disease (NAFLD) and of liver fibrosis associated with nonalcoholic steatohepatitis in unselected patients with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND ..... see more

Source : https://care.diabetesjournals.org/content/early/2020/12/15/dc20-1997.full

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Serum Vitamin D Affected Type 2 Diabetes though Altering Lipid Profile and Modified the Effects of Testosterone on Diabetes Status

Numerous studies have investigated the associations between serum vitamin D or testosterone and diabetes; however, inconsistencies are observed. Whether there is an interaction between vitamin D and testosterone and whether ..... see more

Source : https://www.mdpi.com/2072-6643/13/1/90

35-year-old patient with type 2 diabetes

History of present illness: A 35-year-old female with Type 2 diabetes presents for medication management. She was first diagnosed two years ..... see more

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  • 2 weeks
    Would be helpful to know what her actual lab values were. Consider stool testing for pancreatic insufficiency. Considering her BMI of 19.... Would try her off Metformin and recheck Show More
  • from Generation NP 1 month 2 weeks
    It is unusual for metformin to cause these sx after year. I would start with a I consult, stop the metformin, try an elimination diet. After the elimination diet trial, Show More

35-year-old woman with polyuria

History of present illness: A 35-year old woman presents today for follow-up after recent diagnosis with type 2 diabetes. She was ..... see more

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  • 2 weeks 3 days
    Check UA. Limit caffeine and water intake in evenings. Check glucose during her dizziness, look for hypoglycemia.
  • from Endocrinologist Nation 3 weeks 1 day
    Agree with testing for UTI and downloading glucometer to exclude uncontrolled diabetes is not the cost. Also, exclude hypoglycemia is not occurring when dizzy, instruct her to test during Show More
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Metabolic impact of intermittent fasting in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of interventional studies

You do not currently have access to this article. Subscription prices and ordering Don't already have an Oxford Academic account? Register Metabolic impact of intermittent fasting in patients with type ..... see more

Source : https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgaa926/6034139?redirectedFrom=fulltext

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Natriuretic Effect of Two Weeks of Dapagliflozin Treatment in Patients With Type 2 Diabetes and Preserved Kidney Function During Standardized Sodium Intake: Results of the DAPASALT Trial

OBJECTIVE Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk for heart failure hospitalization potentially by inducing sodium excretion, osmotic diuresis, and plasma volume contraction. Few studies have investigated this hypothesis, ..... see more

Source : https://care.diabetesjournals.org/content/early/2020/12/11/dc20-2604

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Intermittent fasting and 'metabolic switch': Effects on metabolic syndrome, prediabetes and type 2 diabetes - PubMed

Various intermittent fasting (IF) dietary plans have gained popularity among obese individuals in recent years as a means of achieving weight loss. However, studies evaluating the effect of IF regimens ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32372521/

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Potential T2DM drug HMPA promotes short-chain fatty acid production by improving carbon catabolite repression effect of gut microbiota. - ClinOwl

Gut microbiota plays an important role in type 2 diabetes mellitus (T2DM) progression. HMPA (N-(4-hydroxyphenethyl)-3-mercapto-2-methylpropanamide) is a potential T2DM drug screened out in our previous work. This work evaluated the ..... see more

Source : https://clinowl.com/potential-t2dm-drug-hmpa-promotes-short-chain-fatty-acid-production-by-improving-carbon-catabolite-repression-effect-of-gut-microbiota/

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Bariatric surgery for patients with type 2 diabetes mellitus requiring insulin: Clinical outcome and cost-effectiveness analyses

Emma Rose McGlone, Iain Carey, Vladica Veličković, Prem Chana, Kamal Mahawar, Rachel L. Batterham, James Hopkins, Peter Walton, Robin Kinsman, James Byrne Subject Areas For more information about PLOS Subject ..... see more

Source : https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003228

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Sex Differences in the Risk of Coronary Heart Disease Associated With Type 2 Diabetes: A Mendelian Randomization Analysis

OBJECTIVE Observational studies have demonstrated that type 2 diabetes is a stronger risk factor for coronary heart disease (CHD) in women compared with men. However, it is not clear whether ..... see more

Source : https://care.diabetesjournals.org/content/early/2020/12/01/dc20-1137

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Longitudinal analysis of microvascular perfusion and neurodegenerative changes in early type 2 diabetic retinal disease

Aim To prospectively monitor subclinical changes in capillary perfusion and retinal layer thickness in patients with type 2 diabetes and early diabetic retinal disease over 2 years. Methods In this longitudinal ..... see more

Source : https://bjo.bmj.com/content/early/2020/12/08/bjophthalmol-2020-317322

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Association between glycated haemoglobin levels and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease: a secondary analysis of the TECOS randomized clinical trial

Your access to the NCBI website at www.ncbi.nlm.nih.gov has been temporarily blocked due to a possible misuse/abuse situation involving your site. This is not an indication of a security issue ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32621557/