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3 days 23 hours

Association of Cycling With All-Cause and Cardiovascular Disease Mortality Among Persons With Diabetes

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Source : https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2782014

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  • 2 days 22 hours
    cycling was associated with lower all-cause and CVD mortality risk among people with diabetes independent of practicing other types of physical activity.
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3 days 23 hours

Myopia and Early Onset Type 2 Diabetes: A Nationwide Cohort Study

AbstractObjective. A correlation between myopia and insulin-resistance has been suggested. We investigated the association between myopia in adolescence and typ see more

Source : https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgab669/6368107

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  • 2 days 22 hours
    For women, myopia in adolescence was associated with a significantly increased risk for incident T2D in young adulthood, in a severity-dependent manner
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3 days 23 hours

Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation - Nature Communications

Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation - Nature Communications

Identifying causal variants at GWAS loci is important to understand disease mechanisms. Here the authors use massively parallel reporter assays to identify type 2 diabetes-associated variants that alter cis-regulatory activity, ..... see more

Source : https://www.nature.com/articles/s41467-021-25514-6

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  • from Endocrinologist Nation 3 days 9 hours
    Key Points • Conclusion/Relevance: “In this study, we tested 13,252 sequences containing alleles of 6,621 SNPs for their ability to activate and modulate transcription in MIN6 β cells under standard culture conditions Show More
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3 days 23 hours

Comparison of patient- and clinician-reported outcome measures in lower back rehabilitation: introducing a new integrated performance measure (t2D) - Quality of Life Research

Comparison of patient- and clinician-reported outcome measures in lower back rehabilitation: introducing a new integrated performance measure (t2D) - Quality of Life Research

Purpose Patient- and clinician-reported outcome measures (PROMs, CROMs) are used in rehabilitation to evaluate and track the patient's health status and recovery. However, controversy still exists regarding their relevance and ..... see more

Source : https://link.springer.com/article/10.1007/s11136-021-02905-2

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1 week 1 day

Incidence of COVID-19 and Risk of Diabetic Ketoacidosis in New-Onset Type 1 Diabetes - PubMed

Incidence of COVID-19 and Risk of Diabetic Ketoacidosis in New-Onset Type 1 Diabetes - PubMed

1 Division of Pediatric Endocrinology and Diabetology, Centre of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany [email protected] 2 Institute for Biometrics and Epidemiology, German Diabetes Centre, Leibniz Centre ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34011636/

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2 weeks 3 days

Variability in body weight and the risk of cardiovascular complications in type 2 diabetes: results from the Swedish National Diabetes Register - PubMed

Variability in body weight and the risk of cardiovascular complications in type 2 diabetes: results from the Swedish National Diabetes Register - PubMed

High body weight variability predicts the development of cardiovascular complications in type 2 diabetes. These data suggest that any strategy to reduce the body weight in these subjects should be ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34446018/

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  • 1 week 1 day
    High body weight variability predicts the development of cardiovascular complications in type 2 diabetes !!!
  • from Endocrinologist Nation 2 weeks 3 days
    Key Points • Conclusion: “High body weight variability predicts the development of cardiovascular complications in type 2 diabetes. These data suggest that any strategy to reduce the body weight in these Show More
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1 week 3 days

Association between muscle mass, bone mineral density and osteoporosis in type 2 diabetes

Association between muscle mass, bone mineral density and osteoporosis in type 2 diabetes

Type 2 diabetes mellitus is associated with an increased incidence of osteoporosis and sarcopenia. However, the relationship between osteoporosis and sarcopenia in patients with type 2 diabetes mellitus remains to ..... see more

Source : https://onlinelibrary.wiley.com/doi/full/10.1111/jdi.13642

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  • 1 week 1 day
    Screening / Dexa scan should be considered in age appropriate patients as Patients with type 2 diabetes mellitus are generally more prone to fracture than the general population
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1 week 3 days

The relationship between meal carbohydrate quantity and the insulin to carbohydrate ratio required to maintain glycaemia is non-linear in young people with type 1 diabetes: A randomized crossover trial - PubMed

The relationship between meal carbohydrate quantity and the insulin to carbohydrate ratio required to maintain glycaemia is non-linear in young people with type 1 diabetes: A randomized crossover trial - PubMed

doi: 10.1111/dme.14675. Online ahead of print. 1 Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Perth, Western Australia, Australia. 2 Telethon Kids Institute, University of Western Australia, Perth, ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34415640/

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1 week 3 days

Occurrence and predictive factors of high blood pressure, type 2 diabetes, and metabolic syndrome in rheumatoid arthritis: findings from a 3-year, multicentre, prospective, observational study - PubMed

Occurrence and predictive factors of high blood pressure, type 2 diabetes, and metabolic syndrome in rheumatoid arthritis: findings from a 3-year, multicentre, prospective, observational study - PubMed

1 Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy. [email protected] 2 Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy. 3 Department of Clinical and ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33337994/

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1 week 3 days

Association of glycemic variability assessed by continuous glucose monitoring with subclinical diabetic polyneuropathy in type 2 diabetes

Association of glycemic variability assessed by continuous glucose monitoring with subclinical diabetic polyneuropathy in type 2 diabetes

Jiemin Pan , Xinfeng Yan , Fengwen Li , Yinan Zhang , Lan Jiang , Congrong Wang , Corresponding Author Department of Endocrinology and Metabolism, Shanghai Fourth People's Hospital, Tongji ..... see more

Source : https://onlinelibrary.wiley.com/doi/10.1111/jdi.13652?af=R

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2 weeks 3 days

What would be your treatment step to get patient at goal?

56-year old female with type 2 diabetes, BMI of 30 kg/m2 and no major comorbidities, has been on metformin and a sulfonylurea at their highest tolerated doses. Four months ago, her previous physician added a high dose of a DPP-IV inhibitor to help get her to goal of 7%. The treatment regimen brought the A1C to 7.6%. The patient is seeking a second opinion.

Would you consider switching any medications or adding on? Please list what would be your preferred options.

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2 weeks 3 days

Combining CGM and an Online Peer Support Community for Hispanic Adults with T2D: A Feasibility Study.

Background Previous research has identified that people with type 2 diabetes (T2D) within the Hispanic community would benefit from an online peer support community (OPSC) and continuous glucose monitoring (CGM) ..... see more

Source : https://europepmc.org/article/med/34414787

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2 weeks 3 days

Low Plasma Adiponectin in Risk of Type 2 Diabetes: Observational Analysis and One- and Two-Sample Mendelian Randomization Analyses in 756,219 Individuals - PubMed

Low Plasma Adiponectin in Risk of Type 2 Diabetes: Observational Analysis and One- and Two-Sample Mendelian Randomization Analyses in 756,219 Individuals - PubMed

We tested the hypothesis that low plasma adiponectin is observationally and genetic, causally associated with increased risk of type 2 diabetes. Observational analyses are prone to confounding and reverse causation, ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34426507/

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2 weeks 3 days

Effect of Diet Quality and Genetic Predisposition on Hemoglobin A1c and Type 2 Diabetes Risk: Gene-Diet Interaction Analysis of 357,419 Individuals

Effect of Diet Quality and Genetic Predisposition on Hemoglobin A1c and Type 2 Diabetes Risk: Gene-Diet Interaction Analysis of 357,419 Individuals

OBJECTIVE To assess the interactions between diet quality and genetic predisposition to incident type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS Between 2006 and 2010, 357,419 participants with genetic and ..... see more

Source : https://care.diabetesjournals.org/content/early/2021/08/24/dc21-1051

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2 weeks 3 days

Finerenone benefits patients with diabetes across spectrum of kidney disease

Finerenone benefits patients with diabetes across spectrum of kidney disease

ESC Press Office Tel: +33 (0) 7 8531 2036Email: [email protected] Follow us on Twitter @ESCardioNews The hashtag for ESC Congress 2021 is #ESCCongress. This press release accompanies both a presentation ..... see more

Source : https://www.escardio.org/The-ESC/Press-Office/Press-releases/Finerenone-benefits-patients-with-diabetes-across-spectrum-of-kidney-disease

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2 weeks 5 days

Non-insulin treatment for A1C reduction in Type 2 diabetes

Current ADA guidelines recommend:

  • A1C goal for nonpregnant adults of <7% (53 mmol/mol) without significant hypoglycemia is appropriate.
  • Achievement of lower A1C levels than 7% may be acceptable, and even beneficial, if achieved safely without significant hypoglycemia or other adverse effects.
  • A1C goals of <8% [64 mmol/mol] or higher may be appropriate for patients with limited life expectancy, or where the risks outweigh the benefits.


Current ADA guidelines recommend that the medication regimen and medication-taking behavior should be reevaluated at regular intervals (every 3–6 months) and adjusted as needed to incorporate specific factors that impact treatment choice.

How long after starting a diabetes medication do you wait to see if the patient needs to switch or escalate to other non-insulin anti-diabetic treatments?

What are the key considerations when deciding to switch or escalate to other non-insulin anti-diabetic treatments?

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  • 2 weeks 5 days
    Always encourage pt healthy diet & consult with dietician!
  • 1 month
    Can also consider make adjustments based on their Blood glucose readings !
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3 weeks 3 days

Use of once-weekly semaglutide in patients with type 2 diabetes in routine clinical practice: Results from the SURE Canada multicentre, prospective, observational study - PubMed

Use of once-weekly semaglutide in patients with type 2 diabetes in routine clinical practice: Results from the SURE Canada multicentre, prospective, observational study - PubMed

doi: 10.1111/dom.14468. Online ahead of print. 1 McGill University Health Centre, Montreal, Quebec, Canada. 2 Novo Nordisk A/S, Søborg, Denmark. 3 Schulich School of Medicine and Dentistry, Western University, London, ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34142429/

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  • from Endocrinologist Nation 3 weeks 2 days
    Key Points • Conclusion/Relevance: “In SURE Canada, patients treated with OW [once-weekly] semaglutide in routine clinical practice experienced clinically significant improvements in HbA1c, BW [body weight] and other outcomes, supporting semaglutide Show More
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3 weeks 3 days

Long-Term Complications in Youth-Onset Type 2 Diabetes

Our apologies. An error occurred while setting your user cookie. Please set your browser to accept cookies to continue. NEJM.org uses cookies to improve performance by remembering your session ID ..... see more

Source : https://www.nejm.org/doi/full/10.1056/NEJMoa2100165

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3 weeks 3 days

Long-Term Complications in Youth-Onset Type 2 Diabetes - PubMed

Long-Term Complications in Youth-Onset Type 2 Diabetes - PubMed

Among participants who had onset of type 2 diabetes in youth, the risk of complications, including microvascular complications, increased steadily over time and affected most participants by the time of ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34320286/

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3 weeks 3 days

Association of sex-specific differences in lipoprotein(a) concentrations with cardiovascular mortality in individuals with type 2 diabetes mellitus - Cardiovascular Diabetology

Association of sex-specific differences in lipoprotein(a) concentrations with cardiovascular mortality in individuals with type 2 diabetes mellitus - Cardiovascular Diabetology

Background Compared to individuals without type 2 diabetes mellitus, the relative increase in cardiovascular mortality is much higher in women than in men in individuals with type 2 diabetes mellitus. ..... see more

Source : https://cardiab.biomedcentral.com/articles/10.1186/s12933-021-01363-x