In Men With Obesity, T2DM Is Associated With Poor Trabecular Microarchitecture and Bone Strength, and Low Bone Turnover
AbstractIntroduction. Obesity and type 2 Diabetes (T2D) are both associated with greater bone mineral density (BMD) but increased risk of fractures. The effect see more
Sodium-glucose cotransporter 2 inhibitor-induced reduction in the mean arterial pressure improved renal composite outcomes in type 2 diabetes mellitus patients with chronic kidney disease: A propensity score-matched model analysis in Japan - PubMed
The degree of blood pressure reduction after SGLT2 inhibitor treatment influenced renal composite outcomes in Japanese type 2 diabetes mellitus patients with CKD, confirming the importance of blood pressure management ..... see more
Association Between Serum Lipid Levels and Estimated Glomerular Filtration Rate in Type 2 Diabetic Patients.
Introduction Dyslipidemia is a common metabolic abnormality in Type 2 diabetic Mellitus (T2DM) patients with kidney dysfunction. Therefore, the current study was conducted to assess the association between serum lipid ..... see more
Changes in Albuminuria Predict Cardiovascular and Renal Outcomes in Type 2 Diabetes: A Post Hoc Analysis of the LEADER Trial
OBJECTIVE A post hoc analysis to investigate the association between 1-year changes in albuminuria and subsequent risk of cardiovascular and renal events. RESEARCH DESIGN AND METHODS LEADER was a randomized ..... see more
Source : https://care.diabetesjournals.org/content/early/2021/01/25/dc20-1622
Study highlights specific neurons responsible for type 2 diabetes development
Illness is almost never all in your head, but new research from Texas Tech University's Department of Nutritional Sciences suggests a specific group of neurons in the brain may play ..... see more
COL1A1 as a potential new biomarker and therapeutic target for type 2 diabetes - PubMed
Type 2 diabetes (T2D) is a public health problem with a rising incidence worldwide. In this study, a potential new biomarker for T2D and mechanisms underlying the hypoglycemic effects of ..... see more
Metabolic Surgery Superior to Drug Therapy at Controlling Type 2 Diabetes, Study Says
However, "although observational studies of traditional bariatric surgery suggest that diabetes remission can persist long term, it is difficult to extrapolate these findings to the broader population of patients with ..... see more
Specific Dimensions of Depression Have Different Associations With Cognitive Decline in Older Adults With Type 2 Diabetes
OBJECTIVE Depression is highly frequent in older adults with type 2 diabetes and is associated with cognitive impairment, yet little is known about how various depression dimensions differentially affect cognition. ..... see more
Source : https://care.diabetesjournals.org/content/early/2021/01/14/dc20-2031
Potential T2DM drug HMPA promotes short-chain fatty acid production by improving carbon catabolite repression effect of gut microbiota. - ClinOwl
Gut microbiota plays an important role in type 2 diabetes mellitus (T2DM) progression. HMPA (N-(4-hydroxyphenethyl)-3-mercapto-2-methylpropanamide) is a potential T2DM drug screened out in our previous work. This work evaluated the ..... see more
An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease
Some cholesterol-lowering drugs can increase the risk of type 2 diabetes, but the mechanism behind this is not fully understood. Here the authors show that there is a single genetic ..... see more
The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium
The prevalence of type 2 diabetes in youth has increased substantially, yet the genetic underpinnings remain largely unexplored. To identify genetic variants predisposing to youth-onset type 2 diabetes, we formed ..... see more
Source : https://diabetes.diabetesjournals.org/content/early/2021/01/21/db20-0443.abstract
Temporal Trends in Incident Hospitalization for Diabetes-Related Foot Ulcer in Type 2 Diabetes: The Fremantle Diabetes Study - PubMed
doi: 10.2337/dc20-1743. Online ahead of print. 1 Medical School, University of Western Australia, Perth, Western Australia, Australia. 2 Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Murdoch, Western Australia, Australia. ..... see more
Changes in Plant-Based Diet Indices and Subsequent Risk of Type 2 Diabetes in Women and Men: Three U.S. Prospective Cohorts
OBJECTIVE We evaluated the associations between changes in plant-based diets and subsequent risk of type 2 diabetes. RESEARCH DESIGN AND METHODS We prospectively followed 76,530 women in the Nurses' Health ..... see more
Source : https://care.diabetesjournals.org/content/early/2021/01/12/dc20-1636
NIH scientists identify nutrient that helps prevent bacterial infection
Taurine, which helps the body digest fats and oils, could offer treatment benefit. Scientists studying the body's natural defenses against bacterial infection have identified a nutrient - taurine - that ..... see more
Early research shows promise for therapeutics that delay Type 2 Diabetes
Vanderbilt researchers have discovered a unique pathway that initiates islet β cell inflammation-a hallmark of type 2 diabetes-putting them a step closer to developing targeted therapeutics for the disease that ..... see more
Reduced Muscle Strength Is Associated With Insulin Resistance in Type 2 Diabetes Patients With Osteoarthritis
Osteoarthritis, a leading cause of disability, is not only a consequence of aging and mechanical stress on cartilage, but is also associated with metabolic diseases ( 1, 2). Recent studies ..... see more
Source : https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgaa912/6056610?login=true
Calcification of lower extremity arteries is related to the presence of osteoporosis in postmenopausal women with type 2 diabetes mellitus: a cross-sectional observational study
It is unknown whether there is any relationship between extremity arterial macroangiopathy and osteoporosis in type 2 diabetic mellitus (T2DM) patients. We provide evidence to show the association between lower ..... see more
Source : https://link.springer.com/article/10.1007/s00198-020-05775-5