In this cohort study of 1229 individuals who participated in the Look AHEAD trial, incorporating high physical activity volume and weight loss was associated with a 61% of lower risk of adverse CV events.
Sodium-Glucose Cotransporter 2 Inhibitors Reduce the Risk of Hospitalization for Heart Failure and Amputation Rate Compared With Incretin-Based Therapy in Patients With Diabetic Foot Disease: a Nationwide Population-Based Study
Source : https://pubmed.ncbi.nlm.nih.gov/38325629
In patients with type 2 diabetes initially diagnosed with DFC, SGLT2i are effective in significantly reducing the hospitalization for heart failure and MACE rates. SGLT2i lower the amputation rates, especially...
The amputation rates were lower in patients taking SGLT2 inhibitors without lower extremity amputation at the first diabetic foot complication and did not increase in those with a history of peripheral artery disease or lower extremity amputation.
Men with type 2 diabetes experienced accelerated bone loss compared with participants with normoglycemia.
Prevalence and Impact of Diabetes in Patients With Valvular Heart Disease
Source : https://pubmed.ncbi.nlm.nih.gov/38375234/
This study aimed to investigate the prevalence of diabetes in valvular heart disease (VHD), as well as the relationship of diabetes with severity of valvular lesions and clinical outcome. A...
Diabetes was associated with a lower risk of severe aortic and mitral regurgitation, indicating a poor prognosis in patients with mitral regurgitation.
Observational and Genetic Analyses Clarify the Relationship Between Type 2 Diabetes Mellitus and Gallstone Disease
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864641/
The relationship between type 2 diabetes mellitus (T2DM) and gallstone disease (GSD) have been incompletely understood. We aimed to investigate their phenotypic and genetic associations and evaluate the biological mechanisms...
T2DM causally contributes to the development of gallstone disease, but gallstone disease does not increase T2DM risk.
A Study on the Association Between Gut Microbiota, Inflammation, and Type 2 Diabetes
Source : https://link.springer.com/article/10.1007/s00253-024-13041-5
Abstract Type 2 diabetes mellitus (T2DM) was reported to be associated with impaired immune response and alterations in microbial composition and function. However, the underlying mechanism remains elusive. To investigate...
This study presented a fresh perspective on the intricate relationship among the RLRs signaling pathway, gut microbiota, microbial tryptophan derivatives, inflammation, and the prolonged course of T2DM.
Risk Association of the Nitric Oxide Synthase VNTR Intron 4 a/b Variant With Diabetic Nephropathy - a Pilot Study
Source : https://pubmed.ncbi.nlm.nih.gov/38359337
Diabetic nephropathy (DN) is known to be a leading complication of type 2 diabetes mellitus (T2D). This study evaluated whether the VNTR intron 4 a/b and rs1799983 polymorphisms of endothelial-derived...
A significant risk association was observed for the VNTR intron 4 a/b.
A Rare Case Report of Reversible Glucose Counterregulation in an Insulinoma Patient With Type 2 Diabetes
Source : https://link.springer.com/article/10.1007/s12020-024-03703-9
Insulinoma is a neuroendocrine tumor derived from pancreatic β -cells whose clinical manifestation is recurrent hypoglycemia. Insulinoma in a patient with preexisting diabetes is extraordinarily rare, and the unmasking of...
The incidence of insulinoma is low, the clinical manifestations are complex and varied, and some patients have atypical symptoms, which are easily misdiagnosed and mistreated.
Effects of Prediabetes and Type 2 Diabetes on Cognitive Functions
Source : https://link.springer.com/article/10.1007/s12020-024-03720-8
We aimed to investigate the effect of glycemic impairment in prediabetes on cognitive impairment and the impact of glycemic control on cognitive function in patients with diabetes. Materials and methods...
T2DM causes early brain aging and declines cognitive functions since the prediabetic stage.
Patients with T2D who attended the diabetes primary care management program had a 28% lower risk of all-cause dementia incidence compared with patients who did not attend the program and received standard care alone.