Aldehyde Dehydrogenase 2 Activator Augments the Beneficial Effects of Empagliflozin in Mice with Diabetes-Associated HFpEF - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36142350/
1 Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI 48202, USA. 2 Department of Physiology, Wayne State University, Detroit, MI 48202, USA. 3 Department of Neurology, Henry Ford Health System, Detroit, MI 48202, USA. 4 Heart and Vascular Institute, Henry Ford Hospital, Detroit, MI 48202, USA.
Conclusions: AMP-activated protein kinase (AMPK) pathways in ALDH2*2 mice with diabetes-associated HFpEF. This combination was even more effective than EMP alone. Our data indicate that ALDH2 activation along with the treatment of hypoglycemic agents may be a salient strategy to alleviate diabetes-associated HFpEF.