doi: 10.1111/dom.14046. Online ahead of print. 1 National Health and Medical Research Council Clinical Trials Centre, Sydney, New South Wales, Australia. 2 Sydney Medical School, Sydney, New South Wales, Australia. 3 Lipid & Diabetes Research Group, Christchurch Hospital, Christchurch, New Zealand. 4 Heart and Lung Centre, Cardiovascular Research Unit, Helsinki University Central Hospital, Helsinki, Finland.