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Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2 diabetes

Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2 diabetes

Source :

https://link.springer.com/article/10.1007/s00125-020-05212-6

IRS2 is an important molecular switch that mediates insulin signalling in the liver. IRS2 dysregulation is responsible for the phenomenon of selective insulin resistance that is observed in type 2 diabetes. We hypothesise that epigenetic mechanisms are involved in the regulation of IRS2 in the liver of obese and type 2 diabetic individuals.