Highlights
- Reliable detection of SARS-CoV-2 RNA with both the cobas®6800 and NeuMoDx™ SARS-CoV-2 assays.
- Highest sensitivity of SARS-CoV-2 RNA detection in hospitalized symptomatic patients in nasopharyngeal swabs.
- SARS-CoV-2 viral load in anterior nasal swabs comparable to throat swabs.
- High false negative rate of SARS-CoV-2 in saliva...
Interpretation: Previous natural infection was associated with lower incidence of SARS-CoV-2 infection, regardless of the variant, than mRNA primary-series vaccination. Vaccination remains the safest and most optimal tool for protecting against infection and COVID-19-related hospitalisation and death, irrespective of previous infection status.
Interpretation: Our data showed the immunological signature of monkeypox virus infection, characterised by an early expansion of activated effector CD4 and CD8 T cells that persisted over time. Almost all patients, even regardless of HIV infection, developed a poxvirus-specific Th1 cell response. These results might have implications on the...
Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner
Tina Schumann, Santiago Costas Ramon, Nadja Schubert, Mohamad Aref Mayo, Melanie Hega, Katharina Isabell Maser, Servi-Remzi Ada, Lukas Sydow, Mona Hajikazemi, Markus Badstübner, Patrick Müller, Yan Ge, Farhad Shakeri, Andreas...
Our work positions cGAS/STING upstream of tonic IFN signaling in Samhd1-deficient mice and highlights an important role of the pathway in physiological and pathophysiological innate immune priming.
Correlation Between HbA1c Levels and Mortality Rates in Hospitalized COVID-19 Patients
Objective Throughout the coronavirus disease 2019 (COVID-19) pandemic, multiple factors have been associated with poor prognosis for those infected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Age,...
Conclusion: In this study, we show that HbA1c levels, regardless of concurrent comorbidities, are unlikely to be correlated to mortality rates among hospitalized COVID-19 patients. HbA1c levels should not be used as a marker for whether these patients should be admitted to the hospital for further inpatient management or discharged from the...