Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions
Source : https://doi.org/10.1371/journal.ppat.1010832
Author summary The COVID-19 pandemic has ignited efforts to repurpose existing drugs as safe and effective antivirals. Rather than directly inhibiting viral enzymes, host-targeted antivirals inhibit host cell processes to...
Overall, these findings suggest that small GTPases are promising targets for host-targeted antivirals.
A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36423275/
Seasonal influenza vaccines offer little protection against pandemic influenza virus strains. It is difficult to create effective prepandemic vaccines because it is uncertain which influenza virus subtype will cause the...
Our studies indicate that mRNA vaccines can provide protection against antigenically variable viruses by simultaneously inducing antibodies against multiple antigens.
Highlights
- Reliable detection of SARS-CoV-2 RNA with both the cobas®6800 and NeuMoDx™ SARS-CoV-2 assays.
- Highest sensitivity of SARS-CoV-2 RNA detection in hospitalized symptomatic patients in nasopharyngeal swabs.
- SARS-CoV-2 viral load in anterior nasal swabs comparable to throat swabs.
- High false negative rate of SARS-CoV-2 in saliva...
Interpretation: Previous natural infection was associated with lower incidence of SARS-CoV-2 infection, regardless of the variant, than mRNA primary-series vaccination. Vaccination remains the safest and most optimal tool for protecting against infection and COVID-19-related hospitalisation and death, irrespective of previous infection status.
Interpretation: Our data showed the immunological signature of monkeypox virus infection, characterised by an early expansion of activated effector CD4 and CD8 T cells that persisted over time. Almost all patients, even regardless of HIV infection, developed a poxvirus-specific Th1 cell response. These results might have implications on the...