Neutralizing antibody responses 300 days after SARS‐CoV‐2 infection and induction of high antibody titers after vaccination
Source : https://onlinelibrary.wiley.com/doi/10.1002/eji.202149758
Markus Hoffmann , Bernhard Schaaf , Stefan Pöhlmann , Carsten Watzl , Corresponding Author Carsten Watzl Department for Immunology, Leibniz Research Centre for Working Environment and Human Factors (IfADo) at...
Importantly, full COVID-19 vaccination of these individuals resulted in higher antibody titers compared to fully vaccinated individuals in the absence of prior infection. These data demonstrate long-lived antibody-mediated immunity after SARS-CoV-2 infection, and a clear benefit of two vaccine doses for recovered individuals.
Conclusions and Relevance: Among pregnant and postpartum individuals at 17 US hospitals, SARS-CoV-2 infection was associated with an increased risk for a composite outcome of maternal mortality or serious morbidity from obstetric complications.
OP0286 CHARACTERISTICS ASSOCIATED WITH SEVERE COVID-19 OUTCOMES IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE): RESULTS FROM THE COVID-19 GLOBAL RHEUMATOLOGY ALLIANCE (COVID-19 GRA)
Source : https://ard.bmj.com/content/80/Suppl_1/173.2
Background: An increased risk of severe COVID-19 outcomes may be seen in patients with autoimmune diseases on moderate to high daily doses of glucocorticoids, as well as in those with...
Conclusion: Increased age, male sex, glucocorticoid use, chronic renal disease, cardiovascular disease and moderate/high disease activity at time of COVID-19 diagnosis were associated with more severe COVID-19 outcomes in SLE. Potential limitations include possible selection bias (physician reporting), the cross-sectional nature of the data,...
Ongoing 'immune injuries' might cause persistent breathlessness after COVID-19 | Imperial News | Imperial College London
Source : https://www.imperial.ac.uk/news/234518/ongoing-immune-injuries-might-cause-persistent/
Long-lasting immune activity in the airways might be the cause of persistent breathlessness following COVID-19. This is according to a new study of 38 people who were previously hospitalised with...
“Our study found that many months after SARS-CoV-2 infection, there were still abnormal immune cells in the airways of patients with persistent breathlessness. We also identified a protein ‘signature’ in the lungs indicating ongoing injury to the airways.”
Conclusions: Our data suggest that patients with severe asthma or atopic dermatitis on biologic therapies have lower antibody levels after SARS-CoV-2 mRNA vaccination compared to healthy adults. It is unclear if these differences are due to the biologic therapies or confounding factors commonly seen in these patients. Nevertheless, as there is...