Conclusion: Lymphocytes and monocyte ratios inpatient with COVID-19 infection can be used as predictors for the severity of infection. Increased leukocyte count resulted in increases in platelets inpatient with COVID-19.
Highlights
- Prenatal SARS-CoV-2 infection triggers NF-κB-dependent immune activation
- Pregnant women with severe COVID-19 show antiviral IFN-λ signaling
- SARS-CoV-2 infection re-shapes maternal immunity at delivery
- COVID-19-exposed infants exhibit altered neonatal immunity at birth
Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin
Source : https://doi.org/10.1080/21505594.2021.2006960
Abstract Abstract The struggle to control the COVID-19 pandemic is made challenging by the emergence of virulent SARS-CoV-2 variants. To gain insight into their replication dynamics, emergent Alpha (A), Beta...
In conclusion, against the current backdrop of the dominant D variant that could be further complicated by co-infection synergy with new variants, the growing list of viruses susceptible to TG, a promising host-centric antiviral, now includes a spectrum of contemporary SARS-CoV-2 viruses.
Highlights
- Pannexin-1 (Panx-1) is a critical player in COVID-19 lung pathogenesis.
- SARS-CoV-2 Panx-1 channel opening is ACE-2/furin/endocytosis dependent.
- SARS-CoV-2 associated Panx-1 channel opening induces inflammation.
- Blocking Panx-1 channels reduces viral replication and inflammation.
Highlights
- Modeled impacts of different SARS-CoV-2 variants across range of scenarios
- Enhanced transmissibility leads to more infections and narrows margin for control
- Partial immune escape often remains rare and may not limit vaccination impact
- Impact of immune escape is much greater when paired with enhanced transmissibility