Learnings from Implementation Strategies to Improve Lipid Management - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39775142/
Implementation studies are heterogenous in their strategies and design. At the clinician level, multidisciplinary team-based care (including multidisciplinary lipid clinics), pharmacist- or nurse-led interventions, decision-support algorithms or protocols, and educational...
Optimizing lipid management requires multidisciplinary care, patient adherence strategies, EHR utilization, telehealth, and systematic approaches targeting clinicians, patients, and systems, with future research focusing on long-term outcomes, sustainability, and scalability.
The association of atherogenic index of plasma with cardiovascular outcomes in patients with coronary artery disease: A systematic review and meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38566139/
The results of this study demonstrated that increased AIP is an independent prognostic factors in patients with CAD. Further research is warranted to elucidate the potential development of targeted interventions...
Elevated Atherogenic Index of Plasma (AIP) significantly predicts major cardiovascular events, myocardial infarction, cardiovascular death, and revascularization in coronary artery disease, highlighting its prognostic value and potential for targeted interventions.
Protection Strategies Against Palmitic Acid-Induced Lipotoxicity in Metabolic Syndrome and Related Diseases - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39859502/
Diets rich in carbohydrate and saturated fat contents, when combined with a sedentary lifestyle, contribute to the development of obesity and metabolic syndrome (MetS), which subsequently increase palmitic acid (PA)...
Palmitic acid (PA)-induced lipotoxicity in obesity and MetS involves ER stress, mitochondrial dysfunction, and ROS. Protective mechanisms include FFAR activation, lipid droplet storage, and antioxidants to counteract oxidative damage and dysfunction.
Lipotoxicity and immunometabolism in ischemic acute kidney injury: current perspectives and future directions - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38464721/
Dysregulated lipid metabolism is implicated in the pathophysiology of a range of kidney diseases. The specific mechanisms through which lipotoxicity contributes to acute kidney injury (AKI) remain poorly understood. Herein...
Lipotoxicity in ischemic acute kidney injury involves lipid accumulation and mitochondrial dysfunction. A novel "immunometabolic" lipotoxicity mechanism is explored, highlighting potential therapeutic strategies using lipid-lowering medications to mitigate kidney damage.
Lipid-based systems with precipitation inhibitors as formulation approach to improve the drug bioavailability and/or lower its dose: a review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38815207/
Lipid-based systems, such as self-microemulsifying systems (SMEDDS) are attracting strong attention as a formulation approach to improve the bioavailability of poorly water-soluble drugs. By applying the "spring and parachute" strategy...
Supersaturable SMEDDS enhance bioavailability of poorly soluble drugs by maintaining supersaturation using polymers like hypromellose. This approach enables smaller doses, reduced GI irritation, and improved pediatric and elderly formulations.