Combined Probiotic Lactiplantibacillus plantarum ECGC 13110402 and Plant Sterol Supplement May Improve Lipids and Gut Microbiota in Coeliac Adults: A Randomised, Placebo-Controlled Pilot Human Intervention Study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42197276/
Evidence suggests that a gluten-free diet may increase the risk of metabolic abnormalities associated with cardiovascular disease in adults with Coeliac Disease (CeD). This 9-week, double-blind, placebo-controlled, randomised pilot study...
Pilot randomized placebo-controlled study suggests a combined Lactiplantibacillus plantarum ECGC 13110402 and plant sterol/stanol supplement may improve lipid profiles, increase vitamin D levels, and favorably modulate gut microbiota in adults with coeliac disease and hypercholesterolemia.
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Severe hypertriglyceridemia during pregnancy in a hypothyroid patient: A case report and literature review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42148201/
Normal pregnancy causes marked increases in lipids, but in women with underlying dyslipidaemia, this can lead to severe hypertriglyceridemia (triglyceride >1000 mg/dL) and acute pancreatitis. Coexisting conditions like diabetes and...
Case highlights pregnancy-associated severe hypertriglyceridemia in a woman with diabetes and hypothyroidism, complicated by acute pancreatitis, successfully managed using plasmapheresis, insulin infusion, fenofibrate, and coordinated multidisciplinary obstetric care.
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Successful management of Candida auris external ventricular shunt infection: a case report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40764594/
Candida auris ventriculitis can be effectively managed with systemic antifungal therapy and appropriate source control measures.
This case demonstrates successful treatment of rare Candida auris ventriculitis associated with an external ventricular shunt using susceptibility-guided combination antifungal therapy and definitive source control through shunt removal, highlighting importance of aggressive multidisciplinary management.
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Evinacumab Improved the Homozygous Familial Hypercholesterolemia Lipid Metabolism: A Case Report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41062288/
Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder characterized by high levels of low-density lipoprotein cholesterol (LDL-C) and increased risk of early onset atherosclerosis. Evinacumab, an angiopoietin-like protein 3...
This case report shows evinacumab significantly improved lipid profiles and atherosclerosis-related markers in homozygous familial hypercholesterolemia, suggesting broader cardiovascular benefits beyond LDL-cholesterol reduction in refractory disease management.
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Lipid Management for Secondary Prevention in Atherosclerotic Cardiovascular Disease: A Scoping Review and Scientific Report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41423223/
Atherosclerotic cardiovascular disease (ASCVD) is associated with a very high risk of secondary cardiovascular events. Elevated low-density lipoprotein cholesterol (LDL-C) is a major determinant in the progression of ASCVD and...
Aggressive LDL-C reduction is central to secondary ASCVD prevention. Statins, with ezetimibe or PCSK9 inhibitors, lower risk significantly, supporting stricter guideline-recommended LDL-C targets across coronary, cerebrovascular, and peripheral artery disease.
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