Incretin polyagonists as an alternative to bariatric surgery to manage obesity - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41884205/
Incretins are gut hormones involved in maintaining metabolic homeostasis in the human body, and disorders of the incretin system are recognized as contributing to the pathobiology of metabolic dysfunction and...
Review positions incretin polyagonists (e.g., tirzepatide) as potent non-surgical obesity alternatives to bariatric surgery, achieving comparable weight loss, glycemic control, and cardiometabolic benefits via multi-receptor gut hormone effects.
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Falsely decreased triglyceride concentration in a patient with acute pancreatitis due to insufficient configuration of alarm rules - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41710254/
Acute pancreatitis is a potentially life-threatening complication of severe hypertriglyceridemia. The accurate measurement of triglyceride concentration is essential for diagnosis and therapeutic monitoring. This article presents a case of acute...
Case highlights falsely low triglyceride readings in hypertriglyceridemia-induced pancreatitis due to analyzer alarm failure; improved lab protocols, including lipemic index checks and enhanced alerts, are essential for accurate diagnosis.
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The Lipoprotein(a) Implementation Gap: Bridging Evidence and Clinical Practice - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41789317/
Lipoprotein(a) [Lp(a)] represents one of cardiovascular medicine's most profound implementation gaps: a genetically determined risk factor affecting 1.5 billion people worldwide, yet historically underutilized in clinical practice despite overwhelming evidence...
Review highlights major implementation gap in lipoprotein(a) testing despite strong cardiovascular risk evidence. It discusses causal associations, evolving screening guidelines, and emerging RNA-targeted therapies achieving substantial Lp(a) reduction, advancing precision cardiovascular medicine.
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Successful large caloric deficit with high protein modification diet and intensive aerobic and resistance training with progressive overload in adult patient with significant coronary artery disease: a case report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41717581/
Extreme supervised lifestyle intervention may be feasible in carefully selected high-risk CAD patients. Standard moderate programs remain recommended; extreme strategies require intensive medical oversight.
Case report shows supervised intensive lifestyle intervention with high-protein caloric restriction and progressive aerobic-resistance training led to 50-kg weight loss, improved fitness and blood pressure in severe CAD patient without ischemic complications.
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Brimonidine Beyond a Single Specialty: Pharmacological Profile, Dermatologic Applications, and Advances in Drug Delivery Systems - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41683709/
Brimonidine, a highly selective α 2 -adrenergic receptor agonist originally developed for glaucoma treatment, has emerged as an important dermatological agent due to its potent vasoconstrictive and anti-inflammatory properties. This...
Review highlights brimonidine, a selective α2-agonist, for dermatologic use. It reduces rosacea-related erythema via vasoconstriction and anti-inflammatory effects, with minimal systemic absorption. Novel nanocarriers and analogues enhance delivery, efficacy, and therapeutic versatility.
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