Successful large caloric deficit with high protein modification diet and intensive aerobic and resistance training with progressive overload in adult patient with significant coronary artery disease: a case report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41717581/
Extreme supervised lifestyle intervention may be feasible in carefully selected high-risk CAD patients. Standard moderate programs remain recommended; extreme strategies require intensive medical oversight.
Case report shows supervised intensive lifestyle intervention with high-protein caloric restriction and progressive aerobic-resistance training led to 50-kg weight loss, improved fitness and blood pressure in severe CAD patient without ischemic complications.
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Brimonidine Beyond a Single Specialty: Pharmacological Profile, Dermatologic Applications, and Advances in Drug Delivery Systems - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41683709/
Brimonidine, a highly selective α 2 -adrenergic receptor agonist originally developed for glaucoma treatment, has emerged as an important dermatological agent due to its potent vasoconstrictive and anti-inflammatory properties. This...
Review highlights brimonidine, a selective α2-agonist, for dermatologic use. It reduces rosacea-related erythema via vasoconstriction and anti-inflammatory effects, with minimal systemic absorption. Novel nanocarriers and analogues enhance delivery, efficacy, and therapeutic versatility.
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Advances and Perspectives in Curcumin Regulation of Systemic Metabolism: A Focus on Multi-Organ Mechanisms - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41596167/
Curcumin, a natural polyphenol derived from turmeric, functions as a potent exogenous antioxidant and exhibits a range of benefits in the prevention and management of metabolic diseases. Despite its extremely...
Review highlights curcumin’s multi-organ metabolic benefits despite low bioavailability, driven by intestinal accumulation, microbiota modulation, antioxidant (Nrf2), mitochondrial (AMPK/PGC-1α), and anti-inflammatory (NF-κB) pathways, improving insulin resistance, dyslipidemia, and metabolic disease outcomes.
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Advances in the Diagnosis and Management of High-Risk Cardiovascular Conditions: Biomarkers, Intracoronary Imaging, Artificial Intelligence, and Novel Anticoagulants - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41590879/
Understanding thrombosis in acute coronary syndromes (ACSs) has evolved through advances in biomarkers, intracoronary imaging, and emerging analytical tools, improving diagnostic accuracy and risk stratification in high-risk patients. This narrative...
This review highlights advances in ACS care using biomarkers, intracoronary imaging, AI, and novel anticoagulants, enabling improved diagnosis, risk stratification, and personalized management, while emphasizing the need for further validation.
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Progress in risk assessment and management: Forecasting updates across international cholesterol guidelines - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41624043/
In anticipation of updates to cholesterol guidelines globally, evidence since the most recent iteration of recommendations across US and Europe for risk assessment and lipid management are reviewed. ASCVD risk...
Review forecasts global cholesterol guideline updates emphasizing PREVENT risk equations, coronary calcium, lower LDL-C targets, and combination lipid-lowering therapy including statins, ezetimibe, bempedoic acid, and PCSK9 inhibitors for high-risk patients.
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