Unveiling Familial Hypercholesterolemia-Review, Cardiovascular Complications, Lipid-Lowering Treatment and Its Efficacy
Source : https://pubmed.ncbi.nlm.nih.gov/38338916/
Familial hypercholesterolemia (FH) is a genetic disorder primarily transmitted in an autosomal-dominant manner. We distinguish two main forms of FH, which differ in the severity of the disease, namely homozygous...
Familial hypercholesterolemia (FH) is an autosomal-dominant genetic disorder causing high LDL-C levels, leading to premature cardiovascular disease. This review evaluates lipid-lowering therapies and FH's link to early CVD.
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C3G and Ig-MPGN-treatment standard
Source : https://pubmed.ncbi.nlm.nih.gov/37604793/
Among the broad spectrum of membranoproliferative glomerulonephritis (MPGN), immunofluorescence distinguishes C3 glomerulopathy (C3G), with predominant C3 deposits, and immunoglobulin-associated MPGN (Ig-MPGN), with combined C3 and Ig. However, there are several...
Accurate diagnosis and targeted therapies for primary C3G and Ig-MPGN may improve outcomes through unsupervised clustering analysis and ongoing complement cascade-targeting trials.
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Traditional and novel non-statin lipid-lowering drugs
Source : https://pubmed.ncbi.nlm.nih.gov/37979722/
Non-statin drugs find utility in the management of dyslipidaemia in mixed dyslipidaemia, patients with statin intolerance, and when guidelines directed low-density lipoprotein cholesterol (LDL-C) target cannot be achieved despite maximally...
Non-statin drugs are crucial for managing dyslipidaemia in specific patient groups, especially when LDL-C targets are unachievable with statins alone or in cases of statin intolerance.
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Effects of Dietary Carbohydrate Concentration and Glycemic Index on Blood Glucose Variability and Free Fatty Acids in Individuals with Type 1 Diabetes
Source : https://pubmed.ncbi.nlm.nih.gov/38732629/
Monitoring glycemic control status is the cornerstone of diabetes management. This study aimed to reveal whether moderate-carbohydrate (CHO) diets increase the risk of free fatty acid (FFA) levels, and it...
In type 1 diabetes, moderate-carbohydrate diets, regardless of glycemic index, did not significantly impact glycemic control but increased free fatty acid and triglyceride levels, potentially elevating cardiovascular risk.
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Modulating the Gut Microbiota and Metabolites with Traditional Chinese Medicines: An Emerging Therapy for Type 2 Diabetes Mellitus and Its Complications
Source : https://pubmed.ncbi.nlm.nih.gov/38930814/
Currently, an estimated 537 million individuals are affected by type 2 diabetes mellitus (T2DM), the occurrence of which is invariably associated with complications. Glucose-lowering therapy remains the main treatment for...
Traditional Chinese medicines (TCMs) modulate gut microbiota, restoring host homeostasis and ameliorating metabolic disorders, offering a promising approach for managing type 2 diabetes mellitus and its complications with fewer adverse effects.
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