The Role of Antioxidants in the Treatment of Metabolic Dysfunction-Associated Fatty Liver Disease: A Systematic Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39061866/
Non-alcoholic fatty liver disease (NAFLD) is a global public health problem that causes liver-related morbidity and mortality. It is also an independent risk factor for non-communicable diseases. In 2020, a...
Natural antioxidants show greater efficacy than synthetic ones in treating metabolic-associated fatty liver disease (MAFLD), with both human and animal studies highlighting the importance of balancing oxidative stress in therapy.
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Practical Recommendations for the Diagnosis and Management of Lysosomal Acid Lipase Deficiency with a Focus on Wolman Disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39770929/
Lysosomal acid lipase deficiency (LAL-D) is an ultra-rare lysosomal storage disease with two distinct phenotypes, an infantile-onset form (formerly Wolman disease) and a later-onset form (formerly cholesteryl ester storage disease)....
Lysosomal acid lipase deficiency, a rare genetic disorder, requires early diagnosis and urgent enzyme replacement therapy with dietary management—especially in infantile-onset cases—to improve outcomes and reduce high early mortality.
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Perioperative Care of a Child With Molybdenum Cofactor Deficiency - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40322629/
Molybdenum is a trace mineral that is a key component of several enzyme systems. In the human body, molybdenum is complexed with a pterin-based molybdenum cofactor (MOCO), to form the...
Molybdenum cofactor deficiency is a rare, fatal metabolic disorder causing severe neurological damage; this case highlights anesthetic considerations for affected children undergoing surgical procedures like spinal instrumentation.
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Safety and Efficacy of DTX401, an AAV8-Mediated Liver-Directed Gene Therapy, in Adults With Glycogen Storage Disease Type I a (GSDIa) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40064185/
Glycogen storage disease type Ia (GSDIa) is a rare, life-threatening, inherited carbohydrate metabolism disorder caused by glucose-6-phosphatase (G6Pase) deficiency, which is essential for glycogenolysis and gluconeogenesis. GSDIa management includes a...
DTX401 gene therapy for GSDIa showed a favorable safety profile and significantly reduced cornstarch dependency over 52 weeks, improving glucose maintenance without serious treatment-related adverse events in this early-phase trial.
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LDL-Cholesterol-Lowering Effects of a Dietary Supplement Containing Onion and Garlic Extract Used in Healthy Volunteers - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39203947/
Hypercholesterolemia plays a pivotal role in the development and progression of cardiovascular diseases, and its prevention seems to be a crucial healthcare strategy to ameliorate these conditions. Subjects with mild...
A garlic and onion extract significantly reduced LDL and total cholesterol, improved blood pressure, and lowered oxidative and inflammatory markers, suggesting its potential for managing mild hypercholesterolemia safely.
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