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ECC5004, an oral small-molecule GLP-1 receptor agonist, showed promising safety, tolerability, and dose-dependent glucose and weight reduction in early trials, supporting its continued development for T2DM and obesity.

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What’s New in T2D? Highlights from the 2025 ADA Guidelines

The 2025 ADA guidelines introduce key updates that reflect the growing need for personalized, comprehensive diabetes care to address a broader patient population. Among the most notable changes, continuous glucose monitoring (CGM) is now recommended beyond insulin-treated individuals, particularly for adults with type 2 diabetes who are on glucose-lowering therapies who may benefit from real-time glucose insights to improve glycemic control and reduce variability. The guidelines also offer strategies to navigate medication shortages, incorporate additional classes of glucose-lowering agents with cardiovascular and renal benefits, and maintain weight-loss pharmacotherapy beyond initial goals to support long-term metabolic health.

As medication selection continues to evolve, the guidelines emphasize a patient-centered approach that prioritizes cardiovascular, renal, and metabolic health. Beyond glucose lowering, clinicians are encouraged to consider therapy combinations with demonstrated benefits in reducing cardiovascular risk, slowing kidney disease progression, and supporting sustained weight management. New cardiovascular findings reinforce the role of SGLT2 inhibitors, expanding their use in both preserved and reduced ejection fraction heart failure. The guidelines likewise encourage careful patient selection and ongoing monitoring for adverse effects. Additionally, lifestyle-based interventions such as structured nutrition plans, physical activity, and behavioral strategies remain core pillars in achieving metabolic targets.

How will these updates shape your management strategies for adults with type 2 diabetes, particularly in integrating advanced monitoring tools and optimizing heart and kidney protection?

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continous glucose monitoring avoids hypoglcemia an hyperglycemia

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Diabetes-Driven Atherosclerosis: Updated Mechanistic Insights and Novel Therapeutic Strategies - PubMed

Diabetes-Driven Atherosclerosis: Updated Mechanistic Insights and Novel Therapeutic Strategies - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/40076813/

The global rise in diabetes prevalence has significantly contributed to the increasing burden of atherosclerotic cardiovascular disease (ASCVD), a leading cause of morbidity and mortality in this population. Diabetes accelerates...

 

Diabetes accelerates atherosclerosis via hyperglycemia, inflammation, and epigenetic changes. Emerging therapies and precision medicine approaches offer new strategies to reduce residual cardiovascular risk in affected individuals.

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Type 2 Diabetes Mellitus: New Pathogenetic Mechanisms, Treatment and the Most Important Complications - PubMed

Type 2 Diabetes Mellitus: New Pathogenetic Mechanisms, Treatment and the Most Important Complications - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/39940862/

Type 2 diabetes mellitus (T2DM), a prevalent chronic disease affecting over 400 million people globally, is driven by genetic and environmental factors. The pathogenesis involves insulin resistance and β-cell dysfunction,...

 

Type 2 diabetes involves insulin resistance and β-cell dysfunction. Management combines lifestyle changes with pharmacotherapy to control glycemia, reduce complications, and improve quality of life.