1yr
1yr
Is It Time to Move Beyond TIR to TITR? Real-World Data from Over 20,000 Users of Continuous Glucose Monitoring in Patients with Type 1 and Type 2 Diabetes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38444315/
The growing use of continuous glucose monitoring (CGM) has been supported by expert consensus and clinical guidelines on glycemic management in diabetes with time in range (TIR 70-180 mg/dL) representing...
This study analyzed CGM data in 22,006 users, revealing that higher glucose variability (CV) lowers TIR/TITR, with TITR preferred for assessing near-normal glucose levels in T2D compared to T1D.
1yr
Breast cancer and incidence of type 2 diabetes mellitus: a systematic review and meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37656235/
Our findings suggest an elevated risk of T2D in breast cancer survivors, particularly after tamoxifen therapy. Further research is needed to determine the impact of aromatase inhibitors, and chemotherapy on...
This systematic review and meta-analysis found an elevated risk of type 2 diabetes in breast cancer survivors, particularly after tamoxifen therapy, with inconclusive results for aromatase inhibitors and chemotherapy.
1yr
Microglial activation and polarization in type 2 diabetes-related cognitive impairment: A focused review of pathogenesis
Source : https://pubmed.ncbi.nlm.nih.gov/39142542/
Microglia, as immune cells in the central nervous system, are closely related to cognitive impairment associated with type 2 diabetes (T2D). Preliminary explorations have investigated the relationship between T2D-related cognitive...
In summary, microglial activation and polarization in T2D contribute to cognitive impairment by mediating inflammation, neuronal apoptosis, amyloid-β deposition, and Tau phosphorylation, offering potential therapeutic targets for future interventions.
1yr
Type 2 diabetes in children and adolescents: Challenges for treatment and potential solutions
Source : https://pubmed.ncbi.nlm.nih.gov/39369858/
Historically perceived as a disease mainly affecting adults, the prevalence of type 2 diabetes mellitus (T2DM) among children and adolescents has been rising, mirroring the increasing rates of childhood obesity....
Youth-onset T2DM presents unique challenges due to limited therapeutic options and evidence gaps. Continued research and updated guidelines aim to optimize treatment, improve outcomes, and reduce the disease burden on youths.