Metabolic effects of very-low calorie diet, Semaglutide, or combination of the two, in individuals with type 2 diabetes mellitus - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38996661/
VLCD elicited greater short-term losses of weight and fat mass than Semaglutide. Adding VLCD to Semaglutide stimulated further weight loss than Semaglutide alone. The combination did not yield any additive...
VLCD induced greater weight loss than Semaglutide in T2D. Combining both improved beta-cell function but showed no additive weight loss benefits over VLCD alone. Further research on this combination is warranted.
Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control: a 12-month randomised controlled trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38546821/
ClinicalTrials.gov NCT03811587 FUNDING: The project was co-funded by Health~Holland, Top Sector Life Sciences & Health, the Dutch Diabetes Foundation and L-Nutra.
A 12-month RCT found that a monthly 5-day fasting-mimicking diet in type 2 diabetes patients reduced glucose-lowering medication use, improved HbA1c, and led to weight loss, demonstrating safety and efficacy in primary care.
Effectiveness of Different Intervention Modes in Lifestyle Intervention for the Prevention of Type 2 Diabetes and the Reversion to Normoglycemia in Adults With Prediabetes: Systematic Review and Meta-Analysis of Randomized Controlled Trials - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39879607/
PROSPERO CRD42023414313; https://tinyurl.com/55ac4j4n.
Face-to-face interventions significantly reduce T2DM incidence and promote normoglycemia in prediabetes. Digital health shows limited effectiveness, while blended interventions offer moderate benefits. Further research is needed to establish digital health's role in T2DM prevention.
Current barriers to initiating insulin therapy in individuals with type 2 diabetes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38559691/
Insulin is an essential drug in the treatment of diabetes, often necessary for managing hyperglycemia in type 2 diabetes mellitus (T2DM). It should be considered in cases of severe hyperglycemia...
Insulin is essential in T2DM management, but barriers delay initiation. Once-weekly insulins like icodec and BIF may improve adherence, reduce therapeutic inertia, and enhance glycemic control by minimizing hypoglycemia risk and injection burden.
Early effective intervention can significantly reduce all-cause mortality in prediabetic patients: a systematic review and meta-analysis based on high-quality clinical studies - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38495794/
https://www.crd.york.ac.uk/prospero, identifier CRD42020160985.
This systematic review and meta-analysis evaluates early lifestyle or drug interventions for prediabetes, showing significant reductions in all-cause mortality, cardiovascular events, and microvascular complications, particularly for women and younger individuals.