The bidirectional influence between type 2 diabetes mellitus and the state of depression and anxiety - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40419162/
Type 2 diabetes mellitus (T2DM) is a prevalent chronic disease with several complications that has a negative impact on patients' physical and mental health. People's life pressures are increasing as...
Review highlights bidirectional link between type 2 diabetes and depression/anxiety, driven by behavioral and biological mechanisms, with mutual worsening effects and implications for integrated treatment and improved patient outcomes.
Diagnosis and Treatment of Type 2 Diabetes in Adults: A Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40549398/
Type 2 diabetes affects up to 14% of the global population and is associated with preventable long-term complications, such as cardiovascular disease, kidney failure, vision loss, and increased mortality. In...
Type 2 diabetes involves insulin resistance and β-cell dysfunction, diagnosed by glucose/A1C thresholds, managed with lifestyle changes, metformin, and cardioprotective agents (GLP-1RA, SGLT2i) to reduce complications and mortality.
Neurological fallout of hyperglycemia: A case report of a rare presentation of osmotic demyelination syndrome - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41953404/
This case highlights a rare presentation of CPM secondary to hyperosmolar hyperglycemia in the absence of hyponatremia. It underscores the importance of early recognition, neuroimaging, and cautious metabolic correction in...
Severe hyperglycemia can trigger osmotic demyelination syndrome without hyponatremia. This case highlights central pontine myelinolysis presenting with neurological decline, emphasizing early recognition, imaging, and cautious glucose correction for recovery.
Vasculoprotective Effects of Sodium-Glucose Co-Transporter Inhibitors in Non-Diabetic Experimental Settings: A Narrative Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41898437/
Sodium-glucose co-transporter (SGLT) inhibitors are a novel class of glucose-lowering drugs with beneficial pleiotropic effects that have been widely investigated in the past decade in several experimental models and patients...
SGLT inhibitors exhibit vasculoprotective effects independent of glycemic control via anti-inflammatory, antioxidative actions, improved endothelial function, reduced arterial stiffness, and blood pressure, supported by experimental evidence in non-diabetic models.
A Systematic Review and Meta-Analysis of Efficacy and Safety of Liraglutide in Patients with Type 2 Diabetes Mellitus - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41836360/
Liraglutide 1.2 mg and 1.8 mg doses improve weight and glycemic outcomes with a favourable safety profile, supporting its role as an effective therapeutic option for comprehensive management of T2DM...
Meta-analysis (25 RCTs, n=10,593) confirms liraglutide 1.2/1.8 mg significantly reduces weight (-1.24 to -2.81 kg) and HbA1c (-0.24-0.26%) vs. comparators in T2DM with obesity, with favorable GI safety.