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Glucose-lowering drug use, glycemic outcomes, and severe hypoglycemia: 18-Year trends in 0·9 million adults with Diabetes in Hong Kong (2002-2019) - PubMed

Glucose-lowering drug use, glycemic outcomes, and severe hypoglycemia: 18-Year trends in 0·9 million adults with Diabetes in Hong Kong (2002-2019) - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/35789825/

doi: 10.1016/j.lanwpc.2022.100509. 1 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong Special Administrative Region (SAR), China. 2 Hong Kong Institute of...


Conclusion: Following rapid improvement in 2007-2014, glycemic control and SH rates had plateaued despite changing patterns of newer GLDs use in Hong Kong.

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The Effects of Adding Semaglutide to High Daily Dose Insulin Regimens in Patients With Type 2 Diabetes - PubMed

The Effects of Adding Semaglutide to High Daily Dose Insulin Regimens in Patients With Type 2 Diabetes - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/35778801/

Improvement in glycemic control occurred despite reductions in TDD of insulin. Improvements in A1c and body weight were clinically significant. This analysis adds to existing literature supporting the use of...



Conclusion/Relevance: Improvement in glycemic control occurred despite reductions in TDD of insulin. Improvements in A1c and body weight were clinically significant. This analysis adds to existing literature supporting the use of GLP-1 RAs in patients on high daily doses of insulin.


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Type 2 Diabetes and Obesity

Obesity is an important risk factor for type 2 diabetes.1 Both obesity and type 2 diabetes are risk factors for cardiovascular disease.2 Weight management is a key part of the recommended care for patients with type 2 diabetes.3 Lifestyle interventions (diet and exercise) are the cornerstone of management but are not effective for all patients and other interventions, including pharmacotherapy are often required.4 However, approved drug treatments for type 2 diabetes can have positive and negative effects on patients’ weight.5




  • What challenges do you face when trying to achieve weight loss in your patients who have type 2 diabetes?

  • Which drugs treatments indicated for type 2 diabetes are most suitable for patients who are overweight or obese and why?



 



References:




  1. Cameron et al. Quantifying the Sex-Race/Ethnicity-Specific Burden of Obesity on Incident Diabetes Mellitus in the United States, 2001 to 2016: MESA and NHANES. Journal of the American Heart Association. 2021 Feb 16;10(4):e018799.

  2. Scherer and Hill. Obesity, Diabetes, and Cardiovascular Diseases: A Compendium. Circulation Research. 2016 May 27; 118(11): 1703–1705.

  3. Davies et al. Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2018; 61:2461–2498.

  4. Leitner et al. Obesity and Type 2 Diabetes: Two Diseases with a Need for Combined Treatment Strategies - EASO Can Lead the Way. Obesity Facts. 2017 Nov; 10(5): 483–492.

  5. Apovian et al. Body Weight Considerations in the Management of Type 2 Diabetes. Advances in Therapy. 2019; 36(1): 44–58.


  • 3yr
    Lifestyle modification is pretty challenging as we all know we are a society with fast food restaurants around us and we refuse to be active and engage in daily exercise. Show More
  • 3yr
    What other drugs taken in addition to antidiabetic agents lead to weight gain (e.g., antidepressants)? How do you manage weight concerns in such patients?

Show More Comments

  • Saved
Type 2 Diabetes and Obesity

Obesity is an important risk factor for type 2 diabetes.1 Both obesity and type 2 diabetes are risk factors for cardiovascular disease.2 Weight management is a key part of the recommended care for patients with type 2 diabetes.3 Lifestyle interventions (diet and exercise) are the cornerstone of management but are not effective for all patients and other interventions, including pharmacotherapy are often required.4 However, approved drug treatments for type 2 diabetes can have positive and negative effects on patients’ weight.5

  • What challenges do you face when trying to achieve weight loss in your patients who have type 2 diabetes?
  • Which drugs treatments indicated for type 2 diabetes are most suitable for patients who are overweight or obese and why?

 

References:

  1. Cameron et al. Quantifying the Sex-Race/Ethnicity-Specific Burden of Obesity on Incident Diabetes Mellitus in the United States, 2001 to 2016: MESA and NHANES. Journal of the American Heart Association. 2021 Feb 16;10(4):e018799.
  2. Scherer and Hill. Obesity, Diabetes, and Cardiovascular Diseases: A Compendium. Circulation Research. 2016 May 27; 118(11): 1703–1705.
  3. Davies et al. Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2018; 61:2461–2498.
  4. Leitner et al. Obesity and Type 2 Diabetes: Two Diseases with a Need for Combined Treatment Strategies - EASO Can Lead the Way. Obesity Facts. 2017 Nov; 10(5): 483–492.
  5. Apovian et al. Body Weight Considerations in the Management of Type 2 Diabetes. Advances in Therapy. 2019; 36(1): 44–58.
  • 3yr
    Lifestyle modification is pretty challenging as we all know we are a society with fast food restaurants around us and we refuse to be active and engage in daily exercise. Show More
  • 3yr
    Very difficult to convince Hispanics and Asians to decrease rice intake.

Show More Comments

  • Saved
Type 2 Diabetes and Obesity

Obesity is an important risk factor for type 2 diabetes.1 Both obesity and type 2 diabetes are risk factors for cardiovascular disease.2 Weight management is a key part of the recommended care for patients with type 2 diabetes.3 Lifestyle interventions (diet and exercise) are the cornerstone of management but are not effective for all patients and other interventions, including pharmacotherapy are often required.4 However, approved drug treatments for type 2 diabetes can have positive and negative effects on patients’ weight.5




  • What challenges do you face when trying to achieve weight loss in your patients who have type 2 diabetes?

  • Which drugs treatments indicated for type 2 diabetes are most suitable for patients who are overweight or obese and why?



 



References:




  1. Cameron et al. Quantifying the Sex-Race/Ethnicity-Specific Burden of Obesity on Incident Diabetes Mellitus in the United States, 2001 to 2016: MESA and NHANES. Journal of the American Heart Association. 2021 Feb 16;10(4):e018799.

  2. Scherer and Hill. Obesity, Diabetes, and Cardiovascular Diseases: A Compendium. Circulation Research. 2016 May 27; 118(11): 1703–1705.

  3. Davies et al. Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2018; 61:2461–2498.

  4. Leitner et al. Obesity and Type 2 Diabetes: Two Diseases with a Need for Combined Treatment Strategies - EASO Can Lead the Way. Obesity Facts. 2017 Nov; 10(5): 483–492.

  5. Apovian et al. Body Weight Considerations in the Management of Type 2 Diabetes. Advances in Therapy. 2019; 36(1): 44–58.


  • 3yr
    Lifestyle modification is pretty challenging as we all know we are a society with fast food restaurants around us and we refuse to be active and engage in daily exercise. Show More
  • 3yr
    What other drugs taken in addition to antidiabetic agents lead to weight gain (e.g., antidepressants)? How do you manage weight concerns in such patients?

Show More Comments