Type 2 diabetes mellitus accelerates brain aging and cognitive decline: Complementary findings from UK Biobank and meta-analyses
Source : https://elifesciences.org/articles/73138
Patients with Type 2 diabetes show patterns of neurodegeneration consistent with accelerated brain aging, including impaired cognition and loss of brain volume, which are more severe in those with increased...
Conclusions: The neurocognitive impact of T2DM suggests marked acceleration of normal brain aging. T2DM gray matter atrophy occurred approximately 26% ± 14% faster than seen with normal aging; disease duration was associated with increased neurodegeneration. Mechanistically, our results suggest a neurometabolic component to brain aging....
Semaglutide Initiation in a Type 2 Diabetes Mellitus, Post-Liver Transplant Patient - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35610766/
Objective To describe the process of initiation of semaglutide for complex management of type 2 diabetes mellitus (T2DM) in a patient after liver transplantation. Setting Family medicine clinic. Practice Description...
Conclusion: Semaglutide, in addition to basal-bolus insulin therapy, allowed for overall improved glycemic control; however, further studies are needed to evaluate efficacy because of the complexity of diabetes management in this patient population. Throughout the course of treatment of patients with T2DM and organ transplantation, dual...
Discovery of once-weekly, peptide-based selective GLP-1 and cholecystokinin 2 receptors co-agonists - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35594964/
A group of long-acting, peptide-based, and selective GLP-1R/CCK-2R dual agonists were identified by rational design. Guided by sequence analysis, structural elements of the CCK-2R agonist moiety were engineered into the...
Lipoprotein (a) and diabetes mellitus - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35606077/
Lp(a) and diabetes are both known and established risk factors for the development of cardiovascular disease. However, studies trying to link both risk factors find an inverse association between Lp(a)...
Conclusion/Relevance: Only part of the observed association of Lp(a) with diabetes can likely be explained by causality and may also be driven by reverse causation, co-morbidities, or medications. Furthermore, this review also summarizes the role of Lp(a) within patients with diabetes. Several studies suggest that elevated Lp(a) is a causal...
Effect of once-weekly semaglutide versus thrice-daily insulin aspart, both as add-on to metformin and optimized insulin glargine treatment in participants with type 2 diabetes (SUSTAIN 11): a randomized, open-label, multinational, phase 3b trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35546450/
doi: 10.1111/dom.14765. Online ahead of print. 1 Centre for Internal Medicine I, Marienhospital, Stuttgart, Germany. 2 Novo Nordisk A/S, Søborg, Denmark. 3 Department of Internal Diseases Diabetology and Cardiometabolic Diseases,...
Conclusions: In this basal-insulin-treated population, OW semaglutide improved glycemic control to a greater extent than TID IAsp and provided numerically greater weight loss