Characterisation of seven medications approved for attention-deficit/hyperactivity disorder using in vitro models of hepatic metabolism
Source : https://www.tandfonline.com/doi/abs/10.1080/00498254.2022.2141151?journalCode=ixen20
1. The metabolism of most medications approved for the treatment of ADHD is not fully understood. 2. In vitro studies using cryopreserved, plated human hepatocytes (cPHHs) and pooled human liver...
Relevance: The major metabolizing enzyme for methylphenidate and dexmethylphenidate could not be identified using these methods because these compounds were too unstable. Hydrolysis of these medications was spontaneous and did not require the presence of protein to occur.
The impact of Covid-19 pandemic on services for children and adolescents with ADHD: results from a survey of paediatricians in the United Kingdom
Source : https://www.aimspress.com/article/doi/10.3934/publichealth.2022037
Background The Covid-19 pandemic has led to huge disruptions and multi-domain healthcare crisis, with additional impact on children and young people (CYP) affected by Attention Deficit and Hyperactivity Disorder (ADHD)....
Conclusion: The Covid-19 pandemic has had adverse effect on many CYP with ADHD and caused huge disruption to the ADHD services that support them. As the pandemic continues to cause disruptions to ADHD services, the service adaptations emerging from the literature including some of those identified in this study could be useful to support more...
Does training working memory or inhibitory control produce far-transfer improvements in set shifting for children with ADHD? A randomized controlled trial
Source : https://doi.org/10.1080/09297049.2022.2138301
ABSTRACT Children with ADHD show impairments in set shifting task performance. However, the limited available evidence suggests that directly training shifting may not improve shifting performance in this population. We...
Conclusions/Relevance: Taken together, these findings confirm that inhibitory control is important for successful performance on shifting tests, and suggest that training inhibitory control may reflect a method for improving set shifting difficulties in children with ADHD.
Reduced motor planning underlying inhibition of prepotent responses in children with ADHD - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36307452/
To flexibly regulate their behavior, children's ability to inhibit prepotent responses arises from cognitive and motor mechanisms that have an intertwined developmental trajectory. Subtle differences in planning and control can...
Conclusion/Relevance: This strategy might make inhibition harder in naturalistic situations that involve complex actions. Combining cognitive and kinematic measures is a potential innovative method for assessment and intervention of subtle differences in executive processes such as inhibition, going deeper than is possible based on accuracy...
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ADHD Connect3yrKey Points • Source: Scientific Reports • Conclusion: “Combining cognitive and kinematic measures is a potential innovative method for assessment and intervention of subtle differences in executive processes such as inhibition, going deeper than Show More
Reviewing The Cost of Neurodevelopmental Disability | CEOR
Neurodevelopmental delay or disability (NDD) is a significant concern in the care of children across a range of paediatric specialties and often requires long-term, resource intensive multi-disciplinary intervention. Relatively common,...
Conclusion: This review has mapped health economic models used in the evaluation of neurodevelopmental care. While economic analyses in this field are currently scarce, emergent data from common neurodevelopmental disorders was encouraging in the quest for cost-effective care that improves quality of life among these conditions and was often...