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Sleep EEG evidence of delayed brain maturation in attention deficit hyperactivity disorder: a longitudinal study

Sleep EEG evidence of delayed brain maturation in attention deficit hyperactivity disorder: a longitudinal study

Source : https://academic.oup.com/sleep/advance-article-abstract/doi/10.1093/sleep/zsac163/6648473?redirectedFrom=fulltext&login=false

You do not currently have access to this article. Don't already have an Oxford Academic account? Register Sleep EEG evidence of delayed brain maturation in attention deficit hyperactivity disorder: a...



Conclusions: This is the first longitudinal study to reveal electrophysiological evidence of a maturational lag associated with ADHD. In addition, our findings revealed basically unaltered sleep macrostructure but altered sleep homeostasis associated with ADHD.

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Altered neural flexibility in children with attention-deficit/hyperactivity disorder - Molecular Psychiatry

Altered neural flexibility in children with attention-deficit/hyperactivity disorder - Molecular Psychiatry

Source : https://www.nature.com/articles/s41380-022-01706-4

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders of childhood, and is often characterized by altered executive functioning. Executive function has been found to be supported by...



Conclusion: The present study found that neural flexibility is altered in children with ADHD and demonstrated the potential clinical utility of neural flexibility to identify children with ADHD, as well as to monitor treatment responses and disease severity.

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8-year-old boy with ADHD

Justin is in 3rd grade and has trouble with school routines. It is difficult to get him groomed and dressed in the morning, as well as getting his backpack organized. 

At school, Justin’s teachers note that he is very intelligent, but exhibits difficulties focusing and sitting still in class. Except for some topics of interest such as stars, dinosaurs, or animals—on which he can focus intently—he has trouble maintaining focus on other subjects. He is often restless and fidgets in his seat, with his teachers constantly reminding him to sit still and stay on task. Justin also tends to blurt out answers and interrupt with off-topic commentary. When away from his desk, Justin runs around and exhibits difficulty following instructions. Although Justin realizes that he is misbehaving, he says he can’t “stop” himself.

After school, he has trouble completing his homework in a timely manner. The teacher says it should only take 40 minutes to complete the homework given but it takes 2-3 hours while his mother supervises at the kitchen table. His mother reports that he also has trouble with evening routines and winding down before bedtime.   

When choosing a treatment for children with ADHD, how do you rank the following 4 factors: onset of effect, duration of effect, tolerability, and dosing options? 

What other factors do you consider when determining how to treat ADHD?

  • 3yr
    Thanks, All, for your wonderful input! How long does it take to clinically establish onset of effect, duration of effect, tolerability, and dosing options?
  • 3yr
    Most children have difficulty in focusing on subjects which are of little or no interest to them. Has anyone spoken to the teacher to see if the child has an Show More

Show More Comments

  • Saved
8-year-old boy with ADHD

Justin is in 3rd grade and has trouble with school routines. It is difficult to get him groomed and dressed in the morning, as well as getting his backpack organized. 



At school, Justin’s teachers note that he is very intelligent, but exhibits difficulties focusing and sitting still in class. Except for some topics of interest such as stars, dinosaurs, or animals—on which he can focus intently—he has trouble maintaining focus on other subjects. He is often restless and fidgets in his seat, with his teachers constantly reminding him to sit still and stay on task. Justin also tends to blurt out answers and interrupt with off-topic commentary. When away from his desk, Justin runs around and exhibits difficulty following instructions. Although Justin realizes that he is misbehaving, he says he can’t “stop” himself.



After school, he has trouble completing his homework in a timely manner. The teacher says it should only take 40 minutes to complete the homework given but it takes 2-3 hours while his mother supervises at the kitchen table. His mother reports that he also has trouble with evening routines and winding down before bedtime.   



When choosing a treatment for children with ADHD, how do you rank the following 4 factors: onset of effect, duration of effect, tolerability, and dosing options? 



What other factors do you consider when determining how to treat ADHD?


  • 3yr
    Thanks, All, for your wonderful input! How long does it take to clinically establish onset of effect, duration of effect, tolerability, and dosing options?
  • 3yr
    Most children have difficulty in focusing on subjects which are of little or no interest to them. Has anyone spoken to the teacher to see if the child has an Show More

Show More Comments

  • Saved
8-year-old boy with ADHD

Justin is in 3rd grade and has trouble with school routines. It is difficult to get him groomed and dressed in the morning, as well as getting his backpack organized. 



At school, Justin’s teachers note that he is very intelligent, but exhibits difficulties focusing and sitting still in class. Except for some topics of interest such as stars, dinosaurs, or animals—on which he can focus intently—he has trouble maintaining focus on other subjects. He is often restless and fidgets in his seat, with his teachers constantly reminding him to sit still and stay on task. Justin also tends to blurt out answers and interrupt with off-topic commentary. When away from his desk, Justin runs around and exhibits difficulty following instructions. Although Justin realizes that he is misbehaving, he says he can’t “stop” himself.



After school, he has trouble completing his homework in a timely manner. The teacher says it should only take 40 minutes to complete the homework given but it takes 2-3 hours while his mother supervises at the kitchen table. His mother reports that he also has trouble with evening routines and winding down before bedtime.   



When choosing a treatment for children with ADHD, how do you rank the following 4 factors: onset of effect, duration of effect, tolerability, and dosing options? 



What other factors do you consider when determining how to treat ADHD?


  • 3yr
    Thanks, All, for your wonderful input! How long does it take to clinically establish onset of effect, duration of effect, tolerability, and dosing options?
  • 3yr
    Most children have difficulty in focusing on subjects which are of little or no interest to them. Has anyone spoken to the teacher to see if the child has an Show More

Show More Comments