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2yr
A Meta-Analytic Review of the Impact of ADHD Medications on Anxiety and Depression in Children and Adolescents

A Meta-Analytic Review of the Impact of ADHD Medications on Anxiety and Depression in Children and Adolescents

Source : https://link.springer.com/article/10.1007/s00787-022-02004-8

Anxiety and depression are listed as common side effects for medications licensed for treating ADHD in children and adolescents. This meta-analytic review of randomised controlled trials aimed to explore the...

The disparity between evidence from short-term randomised controlled trials and real-world side effect data highlights the importance of establishing and implementing standardised, valid measurements of mental health outcomes in randomised controlled trials of ADHD medications in child and adolescent populations.

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2yr
Adherence, Frequency, and Long-Term Follow-Up of Video Game-Based Treatments in Patients With Attention-Deficit/ Hyperactivity Disorder: a Systematic Review

Adherence, Frequency, and Long-Term Follow-Up of Video Game-Based Treatments in Patients With Attention-Deficit/ Hyperactivity Disorder: a Systematic Review

Source : https://pubmed.ncbi.nlm.nih.gov/37743605/

Video games are useful and effective interventions that can complement traditional treatments in patients with ADHD.

Video games are useful and effective interventions that can complement traditional treatments in patients with ADHD.

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2yr
Illuminating the daily life experiences of adolescents with and without ADHD: protocol for an ecological momentary assessment study

Illuminating the daily life experiences of adolescents with and without ADHD: protocol for an ecological momentary assessment study

Source : https://bmjopen.bmj.com/content/13/9/e077222

Introduction Adolescents with attention-deficit/hyperactivity disorder (ADHD) are at elevated risk of a range of difficulties, among which emotion regulation, peer and co-occurring mental health problems are prominent challenges. To better...

Our findings may be particularly valuable for informing smartphone-based interventions. These show strong promise for adolescents with ADHD because smartphone use is highly embedded within the daily routines of young people, can allow the regular practice of skills within ecological context and can be responsive to incoming data that, for...

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2yr
Pre- and post-treatment evaluation of routine blood analysis in patients with attention deficit hyperactivity disorder and comparison with the healthy control group

Pre- and post-treatment evaluation of routine blood analysis in patients with attention deficit hyperactivity disorder and comparison with the healthy control group

Source : https://www.nature.com/articles/s41598-023-43553-5

This study aimed to examine potential disparities in hematologic inflammation parameters between children diagnosed with attention deficit hyperactivity disorder (ADHD) and their healthy counterparts and to determine whether atomoxetine treatment...

https://www.nature.com/articles/s41598-023-43553-5#Sec8

In this study, inflammation markers were higher in drug-naive ADHD patients than healthy controls. In addition, the improvement in lymphocyte and albumin values after atomoxetine treatment may be valuable in showing the decrease in the severity of inflammation.

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2yr
The clinical appeal of ADHD prodrugs

One benefit of an ADHD prodrug is that its chemical design limits the drug’s abuse potential. In particular, serdexmethylphenidate (SDX) is a prodrug of d-methylphenidate, with lower abuse potential; the performance of SDX following IV administration confirms its decreased appeal for IV drug use. When taken orally and as intended, SDX has a gradual onset and extends the period of d-MPH exposure, which is stoked by the gradual conversion of the prodrug to active d-MPH.

The drug serdexmethylphenidate/dexmethylphenidate (SDX/d-MPH) combines 70% serdexmethylphenidate (Schedule II) and 30% immediate-release d-MPH (Schedule IV). This oral drug results in an earlier onset of action and longer duration of therapy, as well as fewer adverse events because there are no spikes in methylphenidate concentrations. Specifically, d-MPH levels peak at about 2 hours, after which the gradual conversion of SDX to d-MPH kicks in.

What has been your experience using prodrugs, such as SDX/d-MPH, for the treatment of children with ADHD?