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Discontinuation of methylphenidate after long-term exposure in nonhuman primates
Source : https://www.sciencedirect.com/science/article/abs/pii/S0892036223000235?via=ihub
The neurotoxic effects of withdrawal of methylphenidate following long-term use on the developing central nervous system was investigated. * Discontinuation after chronic exposure was not associated with significant changes in brain metabolism and monoamine function. * MicroPET/CT imaging provides minimally invasive biomarkers to assess brain function and neurochemical processes associated with CNS drug use.
Conclusions/Relevance: Discontinuation after chronic exposure was not associated with significant changes in brain metabolism and monoamine function.
• Source: Neurotoxicology and Tetralogy
• Conclusions/Relevance: “This study demonstrates that 6 months after cessation of long-term, chronic MPH [methylphenidate] treatment, there are no significant neurochemical or neural metabolic changes in the central nervous system (CNS) of non-human primates (NHPs) and suggests that microPET imaging is helpful in assessing the status of biomarkers of neurochemical processes linked to chronic CNS drug exposure.”
• U.S. researchers utilized microPET/CT to assess potential neurochemical alterations in the cerebral dopamine system after the discontinuation of long-term MPH administration in NPH. They collected microPET/CT images from adult male rhesus monkeys 6 months after they stopped taking MPH, following 12 years of treatment with the drug.
• MicroPET/CT imaging yields minimally invasive biomarkers of brain function and neurochemical processes linked to chronic CNS drug use.
• “Compared to the vehicle control group, the BPs [binding potentials] of [18F] AV-133 and [18F]-FESP in the striatum were not significantly altered in MPH treated groups. Additionally, no significant differences were detected in the SUVs [standard uptake values] of [18F]-FDG in the MPH treated group compared with control …. microPET imaging is helpful in assessing the status of biomarkers of neurochemical processes linked to chronic CNS drug exposure,” the authors wrote.