Archived multiclass drug resistance might complicate the preservation of HIV RNA suppression.
Divergent Effects of the Antiretroviral Drugs, Dolutegravir, Tenofovir Alafenamide, and Tenofovir Disoproxil Fumarate, on Human Adipocyte Function
Source : https://www.sciencedirect.com/science/article/pii/S0006295223006032?via=ihub
Combined antiretroviral therapy (cART) has been associated with increased body weight accompanied by metabolic alterations in people living with human...
Tenofovir alafenamide and tenofovir disoproxil fumarate both had mild effects on differentiating/differentiated adipocytes but exacerbated some of the dolutegravir effects on cell stress, fibrosis, and hypoxia in human adipocytes.
How Does Intersectionality Impact the Quality of Healthcare Services for Black Women Living With HIV?
Source : https://pubmed.ncbi.nlm.nih.gov/38194323/
Women with HIV are affected more than men by intersecting discriminations. For Black women, additional discrimination can have a detrimental effect on their HIV care. An extended literature review of...
Although Black women with HIV infection reported barriers to health care because of intersectionality, older women who felt confident in their self-identity were more able to cope with issues around this.
A Detailed Characterization of Drug Resistance During Darunavir/Ritonavir Monotherapy Highlights a High Barrier to the Emergence of Resistance Mutations in Protease But Identifies Alternative Pathways of Resistance
Source : https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkad386/7503104?login=false
Maintenance monotherapy with ritonavir-boosted darunavir has yielded variable outcomes and is not recommended.
These findings align with published data from a similar population, indicating a heightened risk of viremia among individuals receiving ritonavir-boosted darunavir monotherapy.
Incidence of Hyperlipidemia Among Adults Initiating Antiretroviral Therapy in the HIV Outpatient Study (HOPS), USA, 2007-2021
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10703529/
Current U.S. guidelines recommend integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) as initial treatment for people with HIV (PWH). We assessed long-term effects of INSTI use on lipid profiles...
People living with HIV infection (PWH) and naïve to antiretroviral therapy receiving routine care with normal lipid profiles had lower rates of incident hyperlipidemia after initiating a RAL-based regimen than a PI-based regimen.