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A 9-year RCT demonstrated that regular multicomponent exercise, including soccer training, effectively counteracts menopause-related declines in cardiometabolic health among hypertensive women. The exercise group showed significant improvements in mean arterial pressure, body weight, fat percentage, cholesterol levels, and LDL cholesterol, compared to controls. Fasting glucose increased in the control group but remained stable in the exercise group, highlighting the long-term benefits of consistent physical activity in managing menopause effects on health.

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Precision Nutrition for Management of Cardiovascular Disease Risk During Menopause

Precision Nutrition for Management of Cardiovascular Disease Risk During Menopause

Source : https://pubmed.ncbi.nlm.nih.gov/39047690/

Considering menopause, women are a clinical population that would greatly benefit from precision nutrition. Future research should explore the use of machine learning and artificial intelligence in a precision nutrition...

Menopause elevates cardiometabolic risk. While DASH and Mediterranean diets improve CVD biomarkers, precision nutrition considering individual factors like genetics and gut microbiome offers targeted strategies.

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Can we predict menopause and premature ovarian insufficiency

Can we predict menopause and premature ovarian insufficiency

Source : https://pubmed.ncbi.nlm.nih.gov/38382699/

The prediction of menopause and premature ovarian insufficiency (POI) involves understanding the factors that contribute to the timing of these events. Menopause is a natural biological process marked by the...

Menopause and POI prediction involves age, AMH, inhibins, FSH, antral follicle counts, and genetic markers, with age being the most predictive, though precise timing remains challenging due to individual variations.

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Non-Hormonal Treatment Options for Moderate to Severe Vasomotor Symptoms

Vasomotor symptoms, such as hot flushes, affect a significant proportion of women during and after menopause. These symptoms result from hormonal changes that alter the hypothalamic thermoneutral zone, making women more sensitive to temperature fluctuations. Neurokinin 3 (NK3) receptor antagonists represent a novel class of non-hormonal treatments designed to target specific pathways involved in regulating body temperature.

Scientific Insights:

  1. Mechanism of Action: NK3 receptor antagonists act on the neurokinin 3 receptors within the central KNDy (kisspeptin, neurokinin B, and dynorphin) neuronal network in the hypothalamus. This network is critical for maintaining body temperature and is disrupted in menopausal women, leading to VMS.
  2. Clinical Efficacy: Recent phase 3 trials have demonstrated that NK3 receptor antagonists significantly reduce the frequency and severity of hot flushes compared to placebo. Studies have reported reductions in hot flush frequency by approximately 56% to 61% with NK3 receptor antagonists, while improvements in VMS severity have been sustained throughout the treatment period.
  3. Comparison with Traditional Non-Hormonal Treatments: Traditional non-hormonal treatments for VMS, such as SSRIs and SNRIs, offer variable efficacy and are associated with side effects like nausea and insomnia. NK3 receptor antagonists provide a targeted approach with efficacy comparable to or better than SSRIs/SNRIs and potentially fewer side effects.
  4. Future Research Directions: Ongoing research is needed to explore the long-term safety and efficacy of NK3 receptor antagonists, especially in populations with contraindications to hormone therapy. Additionally, studies will need to evaluate the impact of these drugs on other health outcomes, such as bone health and cardiovascular events.

How do emerging neurokinin 3 (NK3) receptor antagonists compare to traditional non-hormonal treatments for managing moderate to severe vasomotor symptoms (VMS) associated with menopause?

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  • 1yr
    It’s great to see new therapies develop for such a difficult problem to treat. I have not prescribed the NK3 antagonists yet. Unfortunately, I suspect it will be cost prohibitive Show More
  • 1yr
    I consider this first NK3 receptor antagonist as a game changer. For those women for whom estrogen based hormonal therapy is contraindicated or if they just decline the option Show More

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Insights into the vulvar component of the genitourinary syndrome of menopause (GSM)

Insights into the vulvar component of the genitourinary syndrome of menopause (GSM)

Source : https://pubmed.ncbi.nlm.nih.gov/38704313/

Genitourinary syndrome of menopause is a comprehensive term that groups genital, urinary and sexual signs and symptoms mainly due sex hormone deficiency and aging, with a crucial impact on quality...

Understanding vulvar health in genitourinary syndrome of menopause is vital for targeted treatment, as it influences symptom severity and quality of life, necessitating further research into effective management options.

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