Gynotoxic Effects of Chemotherapy and Potential Protective Mechanisms
Source : https://pubmed.ncbi.nlm.nih.gov/38927992/
Chemotherapy is one of the leading cancer treatments. Unfortunately, its use can contribute to several side effects, including gynotoxic effects in women. Ovarian reserve suppression and estrogen deficiency result in...
Women of reproductive age undergoing chemotherapy are at risk of irreversible ovarian failure. Current methods of determining the ovarian reserve do not accurately predict the future reproductive potential of patients undergoing chemotherapy. Among the most ovotoxic cytostatics are alkylating agents, mainly cyclophosphamide, but the adverse effects of drugs belonging to other groups have also been widely described in the scientific literature.
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Uterine Tumor Resembling Ovarian Sex-Cord Tumor (UTROSCT): A Rare Polyphenotypic Neoplasm
Source : https://pubmed.ncbi.nlm.nih.gov/38928686/
Uterine tumor resembling ovarian sex-cord tumor (UTROSCT) is a rare form of uterine mesenchymal neoplasm. Although UTROSCT generally exhibits benign behavior with a favorable prognosis, this neoplasm is nevertheless classified...
Through our review of the literature, we have determined that UTROSCT is a rare neoplasm. In our opinion, its pathological diagnosis can be difficult for many reasons. First, the neoplasm is rare, and often the diagnosis must be made by an expert in the field. In addition, due to the many histological features that the lesion can show, many differential diagnoses should be considered when the lesion presents as a uterine mass. Moreover, similar to many uterine intra-cavitary and intramural lesions, the most common symptom of this neoplasm is abnormal vaginal bleeding. Thus, this symptom is not useful for diagnosis.
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Gamified Exercise with Kinect: Can Kinect-Based Virtual Reality Training Improve Physical Performance and Quality of Life in Postmenopausal Women with Osteopenia? A Randomized Controlled Trial
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11175348/
Background: Osteopenia, caused by estrogen deficiency in postmenopausal women (PMW), lowers Bone Mineral Density (BMD) and increases bone fragility. It affects about half of older women's social and physical health....
Both groups adhered to the SIOMMMS guidelines, participated in daily outdoor walking for 30 min, and demonstrated improved physical performance and quality of life. However, the experimental group, who received Kinect-based VRT in addition to walking, exhibited more substantial enhancements compared to the control group. The findings suggest that Kinect-based VRT provides additional benefits compared to walking alone in enhancing physical performance and quality of life in PMW with osteopenia.
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Estrogen-immuno-neuromodulation disorders in menopausal depression
Source : https://pubmed.ncbi.nlm.nih.gov/38898454/
A significant decrease in estrogen levels puts menopausal women at high risk for major depression, which remains difficult to cure despite its relatively clear etiology. With the discovery of abnormally...
A significant decrease in estrogen levels disrupts immune homeostasis, particularly the levels of the immune factors TNF-α, IL-1β, IL-4, IL-6, IL-10 and IL-18 through the ERα/ERβ/GPER-associated NLRP3/NF-κB signaling pathway, which involves many signaling molecules, such as TLR2, TLR4, P2X7R, SIRT1, CREB, MS-KIF18A, PI3K, AKT, Gs, cAMP, PKA, PJA1, Serpina3n, Src, and MMP-9.
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Increased nitrate intake from beetroot juice over 4 weeks affects nitrate metabolism, but not vascular function or blood pressure in older adults with hypertension
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11034575/
The decline in vascular function and increase in blood pressure with aging contribute to an increased cardiovascular disease risk. In this randomized placebo-controlled crossover study, we evaluated whether previously reported...
Compared to placebo, plasma and salivary nitrate and nitrite increased at 3H and 4WK POST following nitrate treatment (P < 0.01), suggesting a functioning nitrate-nitrite-NO pathway in the participants of this study. There were no differences between treatments in FBFACh and FBFGTN-area under the curve (AUC) ratios [AUC ratios after (3H POST, 4WK POST) compared with before (PRE) the intervention], or 24-hour ambulatory blood pressure or home blood pressure measures (P > 0.05). These findings do not support the hypothesis that an increased intake of dietary nitrate exerts sustained beneficial effects on FBF or blood pressure in hypertensive older adults, providing important information on the efficacy of nitrate-based interventions for healthy vascular aging.
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