micro-community-banner
 
Profile Image
  • Add Media
  • Saved

1yr
The Association of Race, Ethnicity, and Socioeconomic Status on the Severity of Menopause Symptoms: a Study of 68,864 Women

The Association of Race, Ethnicity, and Socioeconomic Status on the Severity of Menopause Symptoms: a Study of 68,864 Women

Source : https://pubmed.ncbi.nlm.nih.gov/38652870/

Our study suggests that the relationship between race and ethnicity and the severity of menopause symptoms is not solely explained by differences in SES but is itself an independent factor....

The relationship between race/ethnicity and severity of menopause symptoms was not solely explained by differences in socioeconomic status but is itself an independent factor.

Profile Image
  • Saved

1yr
Sexual Dysfunction After Menopause: Guidelines for Assessment and Management

Sexual Dysfunction After Menopause: Guidelines for Assessment and Management

Source : https://pubmed.ncbi.nlm.nih.gov/38777488/

Female sexual dysfunction commonly occurs during the menopause transition and post-menopause due to hormonal, physiologic, and psychosocial factors. Sexuality is important to aging women; however, many are reluctant to seek...

Although the loss of sex hormones (estrogen, progestogens, and androgens) due to natural or iatrogenic menopause can impact sexual function, checking hormone concentrations is not recommended and should not be used to guide treatment.

Profile Image
  • Saved

1yr
Novel MOA targets age-old condition

Hot flashes—experienced by 70%-80% of menopausal women—are physically distressing and worsen quality of life. Newer therapies, such as NK3R antagonists, leverage a non-hormonal approach to addressing these symptoms.

For example, fezolinetant is a selective NK3R antagonist that directly blocks NKB from binding to the KNDy neuron. NKB is a known trigger of vasomotor symptoms (VMS).

KNDy neurons located at the level of the hypothalamus are inhibited by estrogen and triggered by the neuropeptide NKB, thus resulting in the regulation of body temperature.

During menopause, estrogen decline interferes with this balance involving NKB. Left unopposed, NKB signaling increases KNDy neuronal activity. This process sets off heat-dissipation mechanisms, such as vasodilation and sweating (or VMS).

Thus, fezolinetant helps decrease the frequency and intensity of hot flashes and night sweats, honing in on NK3R with an affinity 450 times higher than that of NK1 or NK2 receptors.

What are your thoughts on this new mechanism of action for the treatment of VMS?

Profile Image

Show More Comments

  • Saved

1yr
Dietary Anthocyanin Is Associated With a Lower Prevalence of Hyperuricemia Independently of Metabolic Syndrome Among Females: Results From NHANES 2007-2010 and 2017-2018

Dietary Anthocyanin Is Associated With a Lower Prevalence of Hyperuricemia Independently of Metabolic Syndrome Among Females: Results From NHANES 2007-2010 and 2017-2018

Source : https://pubmed.ncbi.nlm.nih.gov/38742430/

Dietary anthocyanin is associated with a lower prevalence of hyperuricemia independently of MetS among females. Foods rich in anthocyanin should be emphasized for females, especially those aged 40 to 59...

Foods rich in anthocyanin should be emphasized for females, especially those who are menopausal, which may be of potential significance in the prevention of hyperuricemia.

Profile Image
  • Saved

1yr
Does Everyday Discrimination Account for the Increased Risk of Vasomotor Symptoms in Black Women?: the Study of Women's Health Across the Nation (SWAN)

Does Everyday Discrimination Account for the Increased Risk of Vasomotor Symptoms in Black Women?: the Study of Women's Health Across the Nation (SWAN)

Source : https://pubmed.ncbi.nlm.nih.gov/38595299/

Discrimination is associated with greater concurrent risk of any (but not frequent) VMS, and chronic discrimination is associated with a continuously high reporting of any VMS over time, independent of...

For any vasomotor symptom trajectories, chronic discrimination was associated with "continuously high" and "high pre-FMP-decline post-FMP" versus "FMP-onset low" trajectories.

Profile Image