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Advances in lung health and sleep medicine: Key highlights from CHEST 2025

At CHEST 2025 in Chicago, pulmonology experts shared new insights in asthma, COPD, interstitial lung disease, pulmonary hypertension, and sleep medicine. Dr. Sandhya Khurana highlighted emerging asthma data—such as imaging-based reductions in mucus plugging and outcomes in severe asthma with nasal polyps—while also discussing the future of nanobody therapeutics. Dr. Cosmo Fowler reviewed GLP-1 RA–linked survival benefits in OSA.

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case study

Patient Background: A 79-year-old woman presented with persistent hypophosphatemia (serum phosphorus 0.8 mg/dL) and multiple stress fractures involving the ribs, spine, and pelvis, consistent with osteomalacia. Her medical history included type 2 diabetes mellitus, hypertension, obesity, osteoarthritis, and anxiety disorder.

Assessment and Diagnosis: Initial evaluation revealed severe hypophosphatemia (0.8 mg/dL; NR: 2.5–4.5 mg/dL), elevated parathyroid hormone (PTH, 169 pg/mL; NR: 10–65 pg/mL), and normal serum calcium levels. Despite vitamin D supplementation, hypophosphatemia persisted (1.7 mg/dL in 2023), and hypercalcemia developed later (10.9 mg/dL; NR: 8.5–10.2 mg/dL). Renal studies showed phosphate wasting (tubular reabsorption of phosphate [TRP] 56.2%) and elevated fibroblast growth factor 23 (FGF-23, 1694 kRU/L). In 2024, ^18F-fluorocholine PET-CT imaging identified two right parathyroid adenomas, confirming a diagnosis of primary hyperparathyroidism (PHPT).

  1. How can chronic hypophosphatemia signal early-stage PHPT?
  2. Why is postoperative monitoring vital in PHPT care?
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2,4-dinitrophenol intoxication and its morphological findings as an indication of substance intake - PubMed

2,4-dinitrophenol intoxication and its morphological findings as an indication of substance intake - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/39378760/

Lethal intoxications can only very rarely be recognized during an external examination of corpses, as poisoning does not leave any characteristic findings on the deceased. The present study is a...

This review and case report describe 2,4-dinitrophenol intoxication findings, highlighting yellow discoloration in skin, mucosa, and organs as key indicators for diagnosis and toxicological confirmation in fatal poisonings.

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1mo
Asthma control in normal weight and overweight/obese asthmatic children following adenotonsillectomy - PubMed

Asthma control in normal weight and overweight/obese asthmatic children following adenotonsillectomy - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36457155/

ObjectivesChildhood adenotonsillar hypertrophy (ATH) with sleep-disordered breathing (SDB) frequently occurs concomitant with asthma. Adenotonsillectomy and reduction in asthma severity association has been reported. We describe changes in asthma control in...

This prospective cohort trial found that adenotonsillectomy significantly improved asthma control and caregiver quality of life in children with sleep-disordered breathing, with greater benefit in nonobese versus obese/overweight pediatric patients over six months.

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1mo

GLP-1 help reduced wieight and correct blood sugar in type 2 diabetes,also reduced fatty liver disease,ckd,and reduce cariovasculat disaease

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