Impact of Obesity on Atrial Fibrillation Pathogenesis and Treatment Options
Source : https://pubmed.ncbi.nlm.nih.gov/38156451/
Atrial fibrillation (AF) is the most common cardiac arrhythmia. AF increases the risk of stroke, heart failure, dementia, and hospitalization. Obesity significantly increases AF risk, both directly and indirectly, through...
Obesity drives atrial fibrillation through multiple mechanisms, worsening outcomes and impacting treatment efficacy. Weight loss improves AF risk and recurrence, highlighting the need for personalized management strategies.
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Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial
Source : https://pubmed.ncbi.nlm.nih.gov/38078870/
ClinicalTrials.gov Identifier: NCT04660643.
Continued tirzepatide treatment effectively maintains and enhances initial weight loss in individuals with obesity, while withdrawal leads to significant weight regain.
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Obesity and Inflammatory Factors in the Progression of Early-Onset Colorectal Cancer
Source : https://pubmed.ncbi.nlm.nih.gov/38611081/
Metabolic dysfunction associated with obesity leads to a chronic pro-inflammatory state with systemic effects, including the alteration of macrophage metabolism. Tumor-associated macrophages have been linked to the formation of cancer...
Understanding how obesity-related hormones and inflammatory mechanisms contribute to early-onset colorectal cancer can help develop new therapeutic targets and highlight the potential protective role of chemo-preventative agents like aspirin.
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Obesity and body mass index: Past and future considerations in osteoarthritis research
Source : https://pubmed.ncbi.nlm.nih.gov/38354848/
Obesity is an important topic for the osteoarthritis (OA) scientific community. However, the predominant use of body mass index (BMI) to define obesity in OA research is associated with uncertainties...
Future OA research should adopt alternative measures beyond BMI to accurately identify obesity, consider evolving obesity science, and minimize weight stigma to enhance health outcomes for those with or at risk for OA.
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Therapeutic advances in obesity management: an overview of the therapeutic interventions
Source : https://pubmed.ncbi.nlm.nih.gov/38715796/
Obesity has become a global epidemic in the modern world, significantly impacting the global healthcare economy. Lifestyle interventions remain the primary approach to managing obesity, with medical therapy considered a...
The future of obesity management may hinge on personalized medicine, targeting specific components for novel therapeutic agents, while leveraging the efficacy of GLP-1 RAs and bariatric surgery for comprehensive treatment.
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