Obesity-Related Glomerulosclerosis-How Adiposity Damages the Kidneys - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40650024/
Obesity, hypertension, and chronic kidney disease (CKD) constitute the deadly trinity of modern threats for populations of both developed and developing countries. These diseases (together with type 2 diabetes) are...
Obesity, hypertension, and CKD interlink, driving cardiovascular morbidity. Obesity-related glomerulosclerosis arises via inflammatory, compressive, and hemodynamic mechanisms; weight loss, GLP1 agonists, and bariatric surgery offer promising kidney-protective strategies.
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Obesity and its management in primary care setting - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40305970/
Obesity is a worldwide epidemic affecting adults and children, regardless of their socioeconomic status. Significant progress has been made in understanding the genetic causes contributing to obesity, shedding light on...
Obesity impacts all ages globally, causing serious complications. Prevention, especially in children, and treatment through lifestyle, surgery, and new drugs like GLP-1RAs are crucial, with primary care central.
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The GLP-1 agonists work very well. The major problem is Insurance, not covering it to many many people who would benefit from it. It’s heartbreaking to keep this life altering medication from them due to lack of financial resources and lack of insurance coverage.
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Severe obesity with hypo-leptinemia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40128964/
Some cases of obesity are thought to be associated with hypo-leptinemia. This may cause decreased appetite suppression resulting in increased appetite, leading to weight gain. Replacement therapy with leptin might...
A case of severe obesity with hypo-leptinemia, absent leptin gene mutations, suggests possible hypothalamic dysfunction and abnormal adipocyte expansion; leptin-replacement therapy may benefit such patients.
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The Microbiota and Evolution of Obesity - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39673174/
Obesity is a major global concern and is generally attributed to a combination of genetic and environmental factors. Several hypotheses have been proposed to explain the evolutionary origins of obesity...
This review proposes that immune system evolution and pathogen defense (metaflammation), combined with gut microbiota genetics, contribute to obesity's origins, emphasizing a multifactorial, evolutionary and polygenic understanding of the epidemic.
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