Physical activity and anthropometric factors as predictors for postural stability in children - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42203825/
To determine whether anthropometric factors and different domains of physical activity are associated with postural stability outcomes in children. Ninety-five children aged 7-18 years were enrolled in a cross-sectional observational...
Cross-sectional study found that postural stability in children is influenced by age, physical activity, physical education performance, and body weight, with overweight/obesity associated with poorer balance measures and sports participation potentially mitigating some deficits.
Glucagon-Like Peptide-1 Receptor Agonist and Hyponatremia: A Potential Association - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42149072/
Clinicians should consider monitoring serum sodium in patients receiving GLP-1 receptor agonists, particularly when used alongside medications affecting sodium balance, such as thiazide-like diuretic agents.
Case suggests a potential association between tirzepatide and recurrent hyponatremia, particularly with concomitant chlorthalidone use, highlighting the importance of serum sodium monitoring during GLP-1 receptor agonist therapy.
Leptin and leptin resistance in obesity: current evidence, mechanisms and future directions - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40932169/
Leptin, a key adipokine regulating energy homeostasis, has been extensively studied for its potential in the management of obesity. However, its therapeutic efficacy is often limited due to leptin resistance....
This review examines leptin biology and mechanisms of leptin resistance in obesity, highlighting impaired signaling pathways, inflammation, and hyperleptinemia while discussing emerging strategies including leptin sensitization, combination therapies, and MC4R agonists.
How Obesity Complicates Breast Cancer Care: Insights From a Systematic Review of Case Reports - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40568283/
The global rise in obesity has intersected with increasing breast cancer incidence, generating a critical need to understand how excess adiposity affects diagnostic accuracy, treatment delivery, and patient outcomes. Although...
This systematic review highlights how obesity complicates breast cancer care through diagnostic delays, surgical complications, altered drug metabolism, treatment toxicity, and multimorbidity, emphasizing the need for personalized obesity-specific management strategies.
Is there a link between cholesterol-lowering medications and atopic dermatitis? - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41405359/
Effect of CLMs on AD is biologically plausible but clinically unproven. Signals of concern are most consistent for 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and Niemann-Pick C1-Like 1 (NPC1L1) inhibition, whereas...
Cholesterol-lowering drugs may influence atopic dermatitis via skin barrier effects, but evidence is inconclusive; statins/NPC1L1 inhibitors show concern, PCSK9 inhibitors may protect; prioritize cardiovascular benefits while monitoring dermatitis.