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Host transcriptomic signatures of tuberculosis can predict immune reconstitution inflammatory syndrome in HIV patients - PubMed

Host transcriptomic signatures of tuberculosis can predict immune reconstitution inflammatory syndrome in HIV patients - PubMed

Source :

https://pubmed.ncbi.nlm.nih.gov/35398886/

The immune reconstitution inflammatory syndrome (IRIS) can be a complication of anti-retroviral therapy (ART) in patients with advanced HIV, but its pathogenesis is uncertain. In tuberculosis (TB) endemic countries, IRIS is often associated with mycobacterial infections or Bacille Calmette-Guerin (B ...



Conclusion: Parsimonious whole blood transcriptomic signatures for TB showed potential to predict and diagnose IRIS in HIV children and adults.