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Pharmacogenetics of dolutegravir plasma exposure among Southern Africans living with HIV

Pharmacogenetics of dolutegravir plasma exposure among Southern Africans living with HIV

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https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiac174/6580078?login=false

AbstractBackground. Dolutegravir is a component of preferred antiretroviral therapy (ART) regimens. We characterised the pharmacogenetics of dolutegravir exposu



Conclusions: In South Africa, rs887829 and rs28899168 in the UGT1A locus were independently associated with dolutegravir AUCVAR. The novel rs28899168 association warrants replication. This study enhances understanding of dolutegravir pharmacogenetics in Africa.