In Utero Antiretroviral Exposure and Risk of Neurodevelopmental Problems in HIV-Exposed Uninfected 5-Year-Old Children
Source : https://www.liebertpub.com/doi/10.1089/apc.2022.0189
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Conclusion: It remains important to monitor neurodevelopment of CHEU during early childhood and investigate the impact and the role of timing of in utero exposure to specific ARVs.
Weight Change When Initiating, Switching to, and Discontinuing Integrase Strand Transfer Inhibitors in People Living with HIV
Source : https://www.liebertpub.com/doi/10.1089/apc.2022.0203
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Relevance: Further investigations into the relationship between integrase strand transfer inhibitors (INSTIs) and weight gain are required, especially whether ceasing INSTI results in weight loss. We evaluated weight changes associated with different antiretroviral (ARV) regimens.
Rapid-progressing progressive multifocal leukoencephalopathy in two patients newly diagnosed with HIV: case series and review of literature - Journal of NeuroVirology
Source : https://link.springer.com/article/10.1007/s13365-023-01115-5
The JC Polyomavirus (JCPyV) is a virus of global distribution and is usually kept under control by the immune system. In patients with AIDS, a latent JCPyV infection can reactivate...
Conclusions: Patients with neurological symptoms must be a matter of great concern to all doctors. They should be tested for HIV and examined with an MRI of the brain paired with CSF evaluation earlier even with slight clinical lesions. Treatment that targets JCPyV directly is needed and would be highly beneficial for patients with PML,...
Motivations for blood donation by HIV-positive individuals on antiretrovirals in South Africa: A qualitative study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36799902/
We demonstrated a complex interaction between individual, social, cultural, and structural/policy factors in blood donations by PLWH who take ARV. Recommendations to limit HIV + ARV+ donations include: (1) Targeted...
Conclusion: We demonstrated a complex interaction between individual, social, cultural, and structural/policy factors in blood donations by PLWH who take ARV. Recommendations to limit HIV ARV donations include: (1) Targeted communication strategies to increase knowledge among PLWH of their deferral from blood donation-without increasing...
Investigational drugs for HIV: trends, opportunities and key players - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36751107/
While the field focuses on extending dosing intervals, we identify drug tissue penetration as an understudied opportunity to improve HIV care. We repeat that self-administration remains an essential milestone to...
Expert Opinion: While the field focuses on extending dosing intervals, we identify drug tissue penetration as an understudied opportunity to improve HIV care. We repeat that self-administration remains an essential milestone to reach the full potential of long-acting drugs. Treatments and prevention strategies based on broadly neutralizing...