HIV infection of non-classical cells in the brain - Retrovirology
Source : https://retrovirology.biomedcentral.com/articles/10.1186/s12977-023-00616-9
HIV-associated neurological disorders (HAND) affect up to 50% of people living with HIV (PLWH), even in the era of combination antiretroviral therapy (cART). HIV-DNA can be detected in the cerebral...
Relevance: HIV eradication strategies that target persistently infected glia cells will likely be needed to achieve HIV cure.
The 2000HIV study: Design, multi-omics methods and participant characteristics
Source : https://www.frontiersin.org/articles/10.3389/fimmu.2022.982746/full
BackgroundEven during long-term combination antiretroviral therapy (cART), people living with HIV (PLHIV) have a dysregulated immune system, characterized by persistent immune activation, accelerated immune ageing and increased risk of non-AIDS...
Conclusion: The 2000HIV study established a cohort of 1895 PLHIV that employs multi-omics to discover new biological pathways and biomarkers to unravel non-AIDS comorbidities, extreme phenotypes and the latent viral reservoir that impact the health of PLHIV. The ultimate goal is to contribute to a more personalized approach to the best standard...
Indirect Treatment Comparisons of Lenacapavir plus Optimized Background Regimen Versus Other Treatments for Multi-Drug Resistant HIV - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36566886/
Available evidence on the efficacy and effectiveness of different therapies in HTE PWH is sparse. This is the first analysis that provides comparative treatment estimates which can be used alongside...
Conclusion: LEN OBR has statistically significantly greater odds of VS at Week 24-28 than its comparators and represents a novel treatment for people with MDR HIV.
Transmitted drug resistance to integrase based first-line HIV antiretroviral regimens in the Mediterranean Europe - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36571282/
We present the most recent data on TDR to integrase based first-line regimens in Europe. Given the low prevalence of CRR to second generation integrase inhibitors and to first-line NRTIs,...
Conclusions: We present the most recent data on TDR to integrase based first-line regimens in Europe. Given the low prevalence of CRR to second generation integrase inhibitors and to first-line NRTIs, in the years 2018-2021 it is unlikely that newly diagnosed PWH in MeditRes countries would present with baseline resistance to a first-line...
A case report of clinical implications of a delayed antiretroviral therapy switch in a patient with multiple treatment interruptions - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36569036/
The Namibia national antiretroviral therapy guidelines recommend that patients living with HIV who interrupt antiretrovirals and in the process disengage from care be restarted on their usual antiretroviral therapy regimen...
Conclusions: The Namibia national ART guidelines are aligned with the WHO recommendations for a standardized treatment. Nevertheless, regarding patients returning to care after ART interruption, previous ARVs exposure and VL results are essential in guiding the management. To avoid treatment switch delays in patients failing ART, we recommend...