Potential drug-drug interactions due to concomitant medicine use among people living with HIV (PLWH) on antiretroviral therapy in Australia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36434744/
doi: 10.1111/bcp.15614. Online ahead of print. 1 Medicines Intelligence Research Program, School of Population Health - Faculty of Medicine and Health/UNSW Sydney. 2 Centre for Big Data Research in Health...
Conclusions: Concomitant medicine use is widespread amongst PLWH in Australia. Despite a relatively low prevalence of contraindicated medicines, almost a third received medicines that require close monitoring or dose adjustment.
A national household survey on HIV prevalence and clinical cascade among children aged ≤15 years in Kenya (2018)
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0277613
We analyzed data from the 2018 Kenya Population-Based HIV Impact Assessment (KENPHIA), a cross-sectional, nationally representative survey, to estimate the burden and prevalence of pediatric HIV infection, identify associated factors,...
Conclusions/Relevance: The KENPHIA survey confirms a substantial HIV burden among children in Kenya, especially among orphans.
Realizing the promise of long-acting antiretroviral treatment strategies for individuals with HIV and adherence challenges: an illustrative case series - AIDS Research and Therapy
Source : https://aidsrestherapy.biomedcentral.com/articles/10.1186/s12981-022-00477-w
Background Adherence to antiretroviral treatment (ART) remains the cornerstone of optimal HIV outcomes, including viral suppression (VS), immune recovery, and decreased transmission risk. For many people with HIV (PWH), particularly...
Relevance: This paper reports on three young PWH with poor adherence to oral ART and initial viremia being successfully managed with LAI-ART. Although many clinical trials have reported findings on the efficacy, tolerability, or acceptability of LAI-ART, this is one of the first case series that reports on the outcomes of LAI-ART use among...
Regular Testing of HIV and Sexually Transmitted Infections With Self-Collected Samples From Multiple Anatomic Sites to Monitor Sexual Health in Men Who Have Sex With Men: Longitudinal Study
Source : https://formative.jmir.org/2022/11/e40996
Background: Regular HIV and sexually transmitted infection (STI) testing for men who have sex with men (MSM) is an important means of infection prevention, the adoption of which remains suboptimal...
Conclusions: Both baseline prevalence and incidence of STI were high among MSM engaged in regular testing. A high degree of engagement in regular STI and HIV testing was positively associated with incident STI, history of health-seeking behaviors, and perceived convenience of self-sampling. Self-sampling could be introduced as a means of...
Comparison of the design and methodology of Phase 3 clinical trials of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) and dolutegravir-based dual therapy (DTG) in HIV: a systematic review of the literature - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36399521/
doi: 10.1080/14787210.2023.2149490. Online ahead of print. 1 Pharmacy Department, Hospital del Mar, Barcelona, Spain. 2 Department of Infectious Diseases, Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain. 3 CIBERINFEC, Instituto de...
Expert Opinion: The search identified 5, 3 and 2 phase 3 RCTs with BIC/FTC/TAF, DTG/3TC and DTG/RPV, respectively, that met the inclusion criteria. The designs would not be comparable due to differences in pre-randomisation losses, blinding, patient recruitment, as well as differences in methodological quality, with the average score of the...