Impact of antiretroviral therapy in primary HIV infection on natural killer cell function and the association with viral rebound and HIV DNA following treatment interruption
Source : https://www.frontiersin.org/articles/10.3389/fimmu.2022.878743/full
Natural Killer (NK) cells play a key role in controlling HIV replication, with potential downstream impact on the size of the HIV reservoir and likelihood of viral rebound after antiretroviral...
Conclusions: These data show NK cell functions are heterogeneously impacted by HIV infection with a mixed picture of resolution on ART, and that while NK cells may affect HIV DNA levels and time to viral rebound, no single NK cell marker defined delayed viral rebound.
Health insurance coverage, clinical outcomes, and health-related quality of life among youth born to women living with HIV - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36150048/
doi: 10.1097/QAI.0000000000003100. Online ahead of print. 1 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA. 2 Center for Global Health and Mongan Institute, Massachusetts General Hospital,...
Conclusion: These findings suggest meaningful differences in ART adherence and some HR-QoL outcomes by health insurance coverage among young adults born to WLHIV.
Previous Syphilis Not Associated with Neurocognitive Outcomes in People Living with HIV in Ontario, Canada - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36150077/
In this sample, prior syphilis was not associated with worse neurocognitive outcomes over time according to self-reported scales or objective neuropsychological testing.
Conclusions: In this sample, prior syphilis was not associated with worse neurocognitive outcomes over time according to self-reported scales or objective neuropsychological testing.
Inflammation and Intracellular Exposure of Dolutegravir, Darunavir, Tenofovir and Emtricitabine in People living with HIV - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36115063/
doi: 10.1111/bcp.15538. Online ahead of print. 1 Unit of Infectious Diseases, Department of Medical Sciences, University of Turin, Turin, Italy. 2 Laboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical...
Conclusions: Our preliminary data support the hypothesis of lower DRV and DTG IC concentrations and lower TFV plasma exposure in patients with higher plasma IM suggesting an interplay between HIV drug penetration and persistent inflammation in cART-treated HIV-positive patients.
Magnitude and predictors of first-line antiretroviral therapy regimen change among HIV infected adults: A retrospective cross sectional study
Source : https://www.sciencedirect.com/science/article/pii/S2049080122010639?via=ihub
The majorities (57.4%) of the patients were female and the mean age of the study participants was 32.9 ± 9.5 * A total of 165 (21.4%) participants experienced antiretroviral regimen...
Conclusions: The rate of initial HAART regimen change was found to be high. Thus, less toxic and better tolerated HIV treatment options should be available and used more frequently. Moreover, early detection and initiation of ART by the government is highly demanded to maximize the benefit and reduce risk of ART modifications.