A Phase IV Study on Safety, Tolerability and Efficacy of Dolutegravir, | POR
Human Immunodeficiency Virus Type 1 (HIV-1) remains a global health problem with an estimated 37.6 million people globally living with HIV-1 in 2020. Most of these cases were reported from...
Conclusion: This study demonstrated the safety and efficacy of DTG based regimen in treatment naïve HIV-1 patients in Indian population and support use of DTG as first-line treatment regimen.
Effects of the androgen receptor inhibitor enzalutamide on the pharmacokinetics of dolutegravir and tenofovir: a case report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35979833/
Enzalutamide is an androgen receptor inhibitor used for the treatment of prostate cancer. Although enzalutamide causes a favorable adverse effect profile, it might cause drug-drug interactions with some antiretrovirals. No...
Relevance: Enzalutamide is an androgen receptor inhibitor used for the treatment of prostate cancer. Although enzalutamide causes a favorable adverse effect profile, it might cause drug–drug interactions with some antiretrovirals.
Virologic impact of the dolutegravir transition: prospective results from the multinational African Cohort Study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35980350/
doi: 10.1097/QAI.0000000000003065. Online ahead of print. 1 U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA. 2 Henry M. Jackson Foundation for the Advancement...
Conclusion: PLWH transitioning to TLD had higher rates of viral suppression compared to those who remained on other regimens. Even within a highly suppressed population, TLD transition provided significant benefit for achieving or maintaining viral suppression.
Adaption of an ongoing clinical trial to quickly respond to gaps in changing international recommendations: the experience of D 2 EFT - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35938597/
A rapidly changing landscape of antiretrovirals and their procurement at scale has permitted the evaluation of new optimised second-line antiretroviral therapy (ART) in low- and middle-income countries. D 2 EFT...
Conclusion/Relevance: The D2EFT study maintains additional value in a quickly evolving second-line ART strategy allowed by the progress in global access to ART
Efficacy, durability, and tolerability of dolutegravir/lamivudine and dolutegravir/rilpivirine for the treatment of HIV in a real-world setting in Belgium - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35938381/
doi: 10.1111/hiv.13373. Online ahead of print. 1 Saint-Pierre University Hospital, Brussels, Belgium. 2 Cliniques Universitaires Saint-Luc, Brussels, Belgium. 3 Liège University Hospital, Liège, Belgium. 4 Institute of Tropical Medicine, Antwerp,...
Conclusion: In this real-world analysis, the 2DRs analysed were effective, durable, and safe for both treatment-naïve and treatment-experienced patients. A slight increase in weight was associated with these regimens.