Effects of the androgen receptor inhibitor enzalutamide on the pharmacokinetics of dolutegravir and tenofovir: a case report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35979833/
Enzalutamide is an androgen receptor inhibitor used for the treatment of prostate cancer. Although enzalutamide causes a favorable adverse effect profile, it might cause drug-drug interactions with some antiretrovirals. No...
Relevance: Enzalutamide is an androgen receptor inhibitor used for the treatment of prostate cancer. Although enzalutamide causes a favorable adverse effect profile, it might cause drug–drug interactions with some antiretrovirals.
Virologic impact of the dolutegravir transition: prospective results from the multinational African Cohort Study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35980350/
doi: 10.1097/QAI.0000000000003065. Online ahead of print. 1 U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA. 2 Henry M. Jackson Foundation for the Advancement...
Conclusion: PLWH transitioning to TLD had higher rates of viral suppression compared to those who remained on other regimens. Even within a highly suppressed population, TLD transition provided significant benefit for achieving or maintaining viral suppression.
Adaption of an ongoing clinical trial to quickly respond to gaps in changing international recommendations: the experience of D 2 EFT - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35938597/
A rapidly changing landscape of antiretrovirals and their procurement at scale has permitted the evaluation of new optimised second-line antiretroviral therapy (ART) in low- and middle-income countries. D 2 EFT...
Conclusion/Relevance: The D2EFT study maintains additional value in a quickly evolving second-line ART strategy allowed by the progress in global access to ART
Efficacy, durability, and tolerability of dolutegravir/lamivudine and dolutegravir/rilpivirine for the treatment of HIV in a real-world setting in Belgium - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35938381/
doi: 10.1111/hiv.13373. Online ahead of print. 1 Saint-Pierre University Hospital, Brussels, Belgium. 2 Cliniques Universitaires Saint-Luc, Brussels, Belgium. 3 Liège University Hospital, Liège, Belgium. 4 Institute of Tropical Medicine, Antwerp,...
Conclusion: In this real-world analysis, the 2DRs analysed were effective, durable, and safe for both treatment-naïve and treatment-experienced patients. A slight increase in weight was associated with these regimens.
Virological efficacy of switch to DTG plus 3TC in a retrospective observational cohort of suppressed HIV-1 patients with or without past M184V - The LAMRES Study
Source : https://www.sciencedirect.com/science/article/pii/S2213716522001898?via=ihub
In real-life settings, virological rebound after DTG+3TC switch is very low. * M184V in a context of short virological suppression might affect DTG+3TC response. * Further ad hoc clinical trials...
Conclusion/Relevance: A high rate (95%) of VS was observed among children and adolescents on TLD in rural Zimbabwe. TLD may address the problems of virologic failure and emergence of resistance in Africa. However, longer follow up might be needed to ascertain sustained VS in this vulnerable population.