Pharmacological Approaches to Promote Cell Death of Latent HIV Reservoirs
One approach is to combine latency reversal agents with proapoptotic compounds and cytotoxic T cells to first reactivate and then clear infected cells. Other strategies include using natural killer cells...
Achieving a clinically significant reduction in the size of the reservoir will likely require a combination strategy since none of the approaches pursued so far has been successful on its own in clinical trials.
Geometric mean abacavir and lamivudine exposures were higher at 6 to 14 days than at 19- to 24 days of age, whereas they were similar for lopinavir over this period.
Age at ART Initiation and Proviral Reservoir Size in Perinatal HIV-1 Infection: Considerations for ART-Free Remission
The insights gathered from this review serve to inform the field on the unique dynamics of HIV-1 reservoir size in perinatal HIV-1 infection as a function of age at ART...
Despite similar pre-ART baseline HIV-1 DNA levels, very early treatment results in lower levels of HIV-1 DNA in early childhood.
Among people with HIV at low to moderate CV risk, pitavastatin showed promise to reduce noncalcified coronary plaque as well as markers of lipid oxidation and arterial inflammation.
HIV Cure: the Daunting Scale of the Problem
Source : https://pubmed.ncbi.nlm.nih.gov/38359111/
Cure strategies are confounded by basic reservoir biology.
Although shock-and-kill strategies are unlikely to produce the degree of reservoir reduction required for cure, reservoir reduction will facilitate immune control, and thus these strategies may be a useful adjunct to immune-based cure efforts.