Travel Does More Than Widens One's Horizon: Travel History as Key to Diagnosing Blastomycosis
This case report highlights the importance of a detailed travel history and the need to revisit the differential diagnosis when there is an unexpected clinical course. A previously healthy 15-year-old...
Blastomycosis is caused by a dimorphic fungus endemic in certain parts of the United States including areas surrounding the Mississippi and Ohio River valleys, some southeastern states, and areas bordering the Great Lakes. Autochthonous blastomycosis is not seen in Florida. The infection is acquired by inhalation of the organism and is...
The HPV-DNA Test in Pregnancy: A Review of the Literature
Source : https://www.cureus.com/articles/148688-the-hpv-dna-test-in-pregnancy-a-review-of-the-literature
Human papillomavirus (HPV) is a virtually necessary cause of cervical cancer, and HPV genotypes are categorized either as high-risk or low-risk based on their potential to cause malignancy of the...
The HPV-DNA test may constitute a helpful tool utilized for monitoring, risk stratification, and triage of cases that require colposcopy. If combined with the HPV-mRNA test, this might improve its specificity. However, when compared to HPV-DNA detection rates in non-pregnant women, the results were ambiguous, without giving the opportunity to...
Real-world effectiveness of COVID-19 vaccines and anti-SARS-CoV-2 monoclonal antibodies against postacute sequelae of SARS-CoV-2: analysis of a COVID-19 observational registry for a diverse US metropolitan population
Source : https://bmjopen.bmj.com/content/13/4/e067611
Objectives We evaluated the effectiveness of COVID-19 vaccines and monoclonal antibodies (mAbs) against postacute sequelae of SARS-CoV-2 infection (PASC). Design and setting A retrospective cohort study using a COVID-19 specific,...
Conclusion: Although both COVID-19 vaccines and mAbs decreased the likelihood of PASC, vaccination remains the most effective tool for the prevention of long-term consequences of COVID-19.
Interpretation: A 1 + 1 PCV schedule greatly reduces vaccine-type carriage and is likely to generate substantial herd protection and provide some degree of individual protection during the first year of life. Such a schedule is suitable for mature PCV programmes or for introduction in conjunction with a comprehensive catch-up campaign,...
The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence
Source : https://doi.org/10.7554/eLife.84395
Pramod K Jangir , Craig R MacLean , Department of Biology, University of Oxford, United Kingdom; Synthetic and Systems Biology Unit, Biological Research Centre, Eötvös Loránd Research Network, Hungary; Doctoral...
Antimicrobial peptides (AMPs) are a class of antibiotics that are inspired by natural components of innate immunity, which raises the specter of bacteria becoming resistant to both. Jangir et al. test this idea and find compelling evidence that a plasmid that encodes resistance to the AMP colistin also increases resistance to AMPs produced by...