Highlights:
•Patients with MIS-C and COVID-19 have distinct cell injury and host response profiles
•Patients with MIS-C and COVID-19 have elevated solid organ derived cell-free DNA
•Patients with MIS-C have increased endothelial and neuronal derived cell-free RNA
•Cell-free and whole blood RNA provide complementary...
Highlights:
•1,449 plasma proteins are altered by COVID-19 infection, ventilation, or death
•Distinct prognostic models for ventilation and death after COVID-19 infection
•Altered proteins link to Alzheimer’s and coronary artery disease pathways
•Eight proteins are potentially causal for COVID-19 infection
Highlights:
• Transcriptional-translational conflict is tumor suppressive in bladder epithelium
• De-repression of translation elongation enables oncogenic phenotypes
• ARID1A-low tumors are sensitive to drug-induced transcriptional-translational conflict
• Impaired DNA damage response is a collateral effect of gene...
Cytokine storm based mechanisms for extra-pulmonary manifestations of SARS-CoV-2 infection
Source : https://doi.org/10.1172/jci.insight.166012
Viral illnesses like SARS-CoV-2 have pathologic effects on non-respiratory organs in the absence of direct viral infection. We injected mice with cocktails of rodent equivalents of human cytokine storms resulting...
At low doses, COVID-19 cocktails induced glomerular injury and albuminuria in Zhx2 hypomorph and Zhx2+/+ mice to mimic COVID-19 related proteinuria. Common Cold cocktail induced albuminuria selectively in Zhx2 hypomorph mice to model relapse of Minimal Change Disease (MCD), that improved after depletion of TNF-α or sIL-4Rα or IL-6. The Zhx2...
We identified a total of 65 studies from 19 different countries. Our meta-analyses showed that protection from past infection and any symptomatic disease was high for ancestral, alpha, beta, and delta variants, but was substantially lower for the omicron BA.1 variant. Pooled effectiveness against re-infection by the omicron BA.1 variant was...