A single-shot ChAd3-MARV vaccine confers rapid and durable protection against Marburg virus in nonhuman primates - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36516269/
Marburg virus (MARV) causes a severe hemorrhagic fever disease in primates with mortality rates in humans of up to 90%. MARV has been identified as a category A bioterrorism agent...
Protective immunity was achieved within 7 days of vaccination and was maintained through 1 year after vaccination. Antigen-specific antibodies were an immune correlate of protection in the acute challenge model, and their concentration was predictive of protection. These results demonstrate that a single-shot ChAd3-MARV vaccine generated a...
The time between vaccination and infection impacts immunity against SARS-CoV-2 variants
Source : https://doi.org/10.1101/2023.01.02.23284120
As the COVID-19 pandemic continues, long-term immunity against SARS-CoV-2 will be globally important. Official weekly cases have not dropped below 2 million since September of 2020, and continued emergence of...
These results indicate that anti-SARS-CoV-2 antibody responses undergo continual maturation following primary exposure by either vaccination or infection for at least 400 days after last antigen exposure. We show that neutralizing antibody responses improved upon secondary boosting with greater impact seen after extended intervals. Our findings...
Highlights:
• Children have diverse polyclonal SARS-CoV-2-specific naïve T cells.
• Adults have clonally expanded exhausted SARS-CoV-2-specific memory T cells.
• Interferon-activated naïve T cells differentiate into memory T cells in adults but not children.
• Adults but not children develop robust memory T cell responses to...
False-Positive Human Immunodeficiency Virus Results in COVID-19 Patients
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, which causes coronavirus disease 2019 (COVID-19) disease, was first described in 2019 and became a pandemic in 2020. Although it is...
HIV-1 gp41 and SARS-CoV-2 share several structural sequences and motifs. These similarities could explain cross-reactivity and false-positive results when screening for HIV in the presence of COVID. The presence of HIV must be confirmed through more specific laboratory tests such as ELISA.
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Dr Hamid3yrreported 7.2% of COVID-19 cases are associated with other bacterial, fungal, or viral pathogens, which may affect survival rates and treatment options
Amiodarone for the Treatment of Arrhythmias in COVID-19 Patients Does Not Increase the Risk of Pulmonary Fibrosis: A Retrospective Cohort Study
Amiodarone is a class III antiarrhythmic medication used to treat atrial and ventricular tachyarrhythmias. Pulmonary fibrosis from amiodarone use is a well-documented side effect. Pre-COVID-19 pandemic studies have shown that...
The clinical factors associated with the development of pulmonary fibrosis in both groups included a history of preexisting interstitial lung disease (ILD) (p=0.001), exposure to prior radiation therapy (p=0.021), and higher severity of COVID-19 illness (p