Paxlovid-Induced Symptomatic Bradycardia and Syncope
Source : https://www.cureus.com/articles/132780-paxlovid-induced-symptomatic-bradycardia-and-syncope
Paxlovid (nirmatrelvir/ritonavir) is a game changer in the fight against COVID-19 due to its ease of administration and significant benefits of reducing progression to severe COVID-19, hospitalization, and death. Cardiac...
Conclusions: We hereby report a potential association between Paxlovid use and sinus node dysfunction. More data is needed to support this association, until then caution may be advised while using Paxlovid, especially in patients with a history of vasovagal syncope.
Researchers discover exploiting microbiome bacteria in patients with lung infections improves low oxygen levels
Source : https://medicalxpress.com/news/2023-01-exploiting-microbiome-bacteria-patients-lung.html
Newspaper headlines from the U.S. to the U.K. and most places in between highlight the surge in sick patients suffering from respiratory viruses. The so-called "tripledemic" of lung infections including...
Therefore, the administration of SLAB51 offers a complementary approach to standard care for treating the hypoxia observed during not just COVID-19 infections but other respiratory viruses such as respiratory syncytial virus (RSV) and the flu.
Here, we show that the macrophage phagocytic receptor TREM2, induced by hepatocyte-derived sphingosine-1-phosphate, was required for efferocytosis of lipid-laden apoptotic hepatocytes and thereby maintained liver immune homeostasis.
Does COVID change the body's response to other threats? Depends on your sex
Source : https://news.yale.edu/2023/01/04/does-covid-change-bodys-response-other-threats-depends-your-sex
The long-term effects of infection on the immune system have long intrigued John Tsang, a Yale immunobiologist. After the body has faced down a pathogen, does the immune system return...
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In essence, the baseline immune statuses in men previously infected with SARS-CoV-2 was altered in ways that changed the response to an exposure different from SARS-CoV-2, the authors said.
Mitogen Activated Protein Kinase (MAPK) Activation, p53, and Autophagy Inhibition Characterize the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein Induced Neurotoxicity
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and prions use common pathogenic pathways to induce toxicity in neurons. Infectious prions rapidly activate the p38 mitogen activated protein...
We conclude that, according to the age of the spike protein-exposed patient and the state of their cellular autophagy activity, excess sustained activity of p53 in neurons may be a catalytic factor in neurodegeneration. An autoimmune reaction via molecular mimicry likely also contributes to neurological symptoms. Overall results suggest that...